6gd8: Difference between revisions

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-'''Unreleased structure'''
-The entry 6gd8 is ON HOLD
+==Cytochrome c in complex with Sulfonato-calix[8]arene, P31 form==
+<StructureSection load='6gd8' size='340' side='right' caption='[[6gd8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gd8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GD8 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EVB:sulfonato-calix[8]arene'>EVB</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6gd6|6gd6]], [[6gd7|6gd7]], [[6gd9|6gd9]], [[6gda|6gda]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYC1, YJR048W, J1653 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gd8 OCA], [http://pdbe.org/6gd8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gd8 RCSB], [http://www.ebi.ac.uk/pdbsum/6gd8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gd8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Controlled protein assembly provides a means to regulate function. Supramolecular building blocks, including rigid macrocycles, have proven to be versatile triggers of protein assembly. Here, we show that sulfonato-calix[8]arene (sclx8) mediates the formation of cytochrome c tetramers in solution. This tetramer spontaneously disassembles at &gt;/= 2 equivalents of sclx8 providing a remarkable example of "auto-regulation". Using X-ray crystallography we characterize in detail the sclx8 binding sites on cytochrome c. Crystal structures at different protein-ligand ratios reveal varying degrees (up to ~35 %) of protein surface coverage by the calixarene and suggest a mechanism for oligomer disassembly. The solution structure of the oligomer was characterized by small angle X-ray scattering. Overall, the data indicate calixarene-controlled protein assembly and disassembly without the requirement for a competitive inhibitor, and point to protein encapsulation by a flexible macrocycle.
-Authors: Rennie, M.L., Fox, G.C., Crowley, P.B.
+Auto-regulated Protein Assembly on a Supramolecular Scaffold.,Rennie M, Fox G, Perez J, Crowley PB Angew Chem Int Ed Engl. 2018 Aug 15. doi: 10.1002/anie.201807490. PMID:30109907<ref>PMID:30109907</ref>
-Description: Cytochrome c in complex with Sulfonato-calix[8]arene, P31 form
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Crowley, P.B]]
+<div class="pdbe-citations 6gd8" style="background-color:#fffaf0;"></div>
-[[Category: Rennie, M.L]]
+== References ==
-[[Category: Fox, G.C]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Baker's yeast]]
+[[Category: Crowley, P B]]
+[[Category: Fox, G C]]
+[[Category: Rennie, M L]]
+[[Category: Assembly]]
+[[Category: Calixarene]]
+[[Category: Oxidoreductase]]
+[[Category: Scaffold]]
+[[Category: Supramolecular]]