6c55: Difference between revisions

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-'''Unreleased structure'''
-The entry 6c55 is ON HOLD  until Paper Publication
+==Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3==
+<StructureSection load='6c55' size='340' side='right'caption='[[6c55]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6c55]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_RF122 Staphylococcus aureus RF122]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C55 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EKA:[cyclohexyl(hydroxy)amino](oxo)acetic+acid'>EKA</scene>, <scene name='pdbligand=EKD:(cyclohexylamino)(oxo)acetic+acid'>EKD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c55 OCA], [https://pdbe.org/6c55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c55 RCSB], [https://www.ebi.ac.uk/pdbsum/6c55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c55 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ILVC_STAAB ILVC_STAAB] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
-Authors:
+==See Also==
+*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]
-Description:
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Staphylococcus aureus RF122]]
+[[Category: Guddat LW]]
+[[Category: Kandale A]]
+[[Category: McGeary RP]]
+[[Category: Patel KM]]
+[[Category: Schenk G]]
+[[Category: Schmbri M]]
+[[Category: You L]]
+[[Category: Zheng S]]