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[[Image:2h74.jpg|left|200px]]


{{Structure
==Crystal Structure of Thioredoxin Mutant D2E in Hexagonal (p61) Space Group==
|PDB= 2h74 |SIZE=350|CAPTION= <scene name='initialview01'>2h74</scene>, resolution 2.400&Aring;
<StructureSection load='2h74' size='340' side='right'caption='[[2h74]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
<table><tr><td colspan='2'>[[2h74]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H74 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.7.1.4 4.7.1.4] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h74 OCA], [https://pdbe.org/2h74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h74 RCSB], [https://www.ebi.ac.uk/pdbsum/2h74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h74 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2trx|2TRX]], [[1zzy|1ZZY]], [[2fch|2FCH]], [[2fd3|2FD3]], [[2h6x|2H6X]], [[2h6y|2H6Y]], [[2h7z|2H7Z]], [[2h70|2H70]], [[2h71|2H71]], [[2h72|2H72]], [[2h73|2H73]], [[2h75|2H75]], [[2h76|2H76]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h74 OCA], [http://www.ebi.ac.uk/pdbsum/2h74 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h74 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/2h74_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h74 ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of Thioredoxin Mutant D2E in Hexagonal (p61) Space Group'''
==See Also==
 
*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2H74 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H74 OCA].
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Lyase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Gavira JA]]
[[Category: Gavira, J A.]]
[[Category: Godoy-Ruiz R]]
[[Category: Godoy-Ruiz, R.]]
[[Category: Ibarra-Molero B]]
[[Category: Ibarra-Molero, B.]]
[[Category: Sanchez-Ruiz JM]]
[[Category: Sanchez-Ruiz, J M.]]
[[Category: alpha beta]]
[[Category: electron transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:26:26 2008''

Latest revision as of 12:53, 30 August 2023

Crystal Structure of Thioredoxin Mutant D2E in Hexagonal (p61) Space GroupCrystal Structure of Thioredoxin Mutant D2E in Hexagonal (p61) Space Group

Structural highlights

2h74 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THIO_ECOLI Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2h74, resolution 2.40Å

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