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[[Image:2gjm.gif|left|200px]]


{{Structure
==Crystal structure of Buffalo lactoperoxidase at 2.75A resolution==
|PDB= 2gjm |SIZE=350|CAPTION= <scene name='initialview01'>2gjm</scene>, resolution 2.75&Aring;
<StructureSection load='2gjm' size='340' side='right'caption='[[2gjm]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>
<table><tr><td colspan='2'>[[2gjm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJM FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjm OCA], [https://pdbe.org/2gjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjm RCSB], [https://www.ebi.ac.uk/pdbsum/2gjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjm ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjm OCA], [http://www.ebi.ac.uk/pdbsum/2gjm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gjm RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjm ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Buffalo lactoperoxidase at 2.75A resolution'''
==See Also==
 
*[[Lactoperoxidase|Lactoperoxidase]]
 
== References ==
==About this Structure==
<references/>
2GJM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA].
__TOC__
</StructureSection>
[[Category: Bubalus bubalis]]
[[Category: Bubalus bubalis]]
[[Category: Peroxidase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Ethayathulla AS]]
[[Category: Ethayathulla, A S.]]
[[Category: Sharma S]]
[[Category: Sharma, S.]]
[[Category: Sheikh IA]]
[[Category: Sheikh, I A.]]
[[Category: Singh AK]]
[[Category: Singh, A K.]]
[[Category: Singh N]]
[[Category: Singh, N.]]
[[Category: Singh TP]]
[[Category: Singh, T P.]]
[[Category: buffalo]]
[[Category: crystal structure]]
[[Category: lactoperoxidase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:17:33 2008''

Latest revision as of 11:04, 30 October 2024

Crystal structure of Buffalo lactoperoxidase at 2.75A resolutionCrystal structure of Buffalo lactoperoxidase at 2.75A resolution

Structural highlights

2gjm is a 1 chain structure with sequence from Bubalus bubalis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.75Å
Ligands:, , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PERL_BUBBU Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ozdemir H, Hacibeyoglu HI, Uslu H. Purification of lactoperoxidase from creek-water buffalo milk and investigation of kinetic and antibacterial properties. Prep Biochem Biotechnol. 2002 May;32(2):143-55. PMID:12071645 doi:http://dx.doi.org/10.1081/PB-120004127

2gjm, resolution 2.75Å

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