6g2m: Difference between revisions
New page: '''Unreleased structure''' The entry 6g2m is ON HOLD until Paper Publication Authors: Pachl, P., Rezacova, P., Brynda, J. Description: Crystal structure of human mitochondrial 5'(3')-d... |
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==Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU== | |||
<StructureSection load='6g2m' size='340' side='right' caption='[[6g2m]], [[Resolution|resolution]] 1.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g2m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2M FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O84:[(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic+acid'>O84</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g22|6g22]], [[6g2l|6g2l]], [[6g2n|6g2n]]</td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2m OCA], [http://pdbe.org/6g2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2m RCSB], [http://www.ebi.ac.uk/pdbsum/6g2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2m ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Brynda, J]] | [[Category: Brynda, J]] | ||
[[Category: Pachl, P]] | [[Category: Pachl, P]] | ||
[[Category: Rezacova, P]] | |||
[[Category: 5'-nucleotidase]] | |||
[[Category: Dephosphorylation]] | |||
[[Category: Had-like]] | |||
[[Category: Hydrolase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Mitochondria]] | |||
[[Category: Phosphorylation]] | |||