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[[Image:2g8d.gif|left|200px]]


{{Structure
==Lactobacillus casei thymidylate synthase Y261W-dUMP complex==
|PDB= 2g8d |SIZE=350|CAPTION= <scene name='initialview01'>2g8d</scene>, resolution 2.40&Aring;
<StructureSection load='2g8d' size='340' side='right'caption='[[2g8d]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=UMP:2&#39;-DEOXYURIDINE+5&#39;-MONOPHOSPHATE'>UMP</scene>
<table><tr><td colspan='2'>[[2g8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8D FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= thya ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1582 Lactobacillus casei])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8d OCA], [https://pdbe.org/2g8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8d RCSB], [https://www.ebi.ac.uk/pdbsum/2g8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8d ProSAT]</span></td></tr>
|RELATEDENTRY=[[2g86|2G86]], [[2g89|2G89]], [[2g8a|2G8A]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8d OCA], [http://www.ebi.ac.uk/pdbsum/2g8d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g8d RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8d ConSurf].
<div style="clear:both"></div>


'''Lactobacillus casei thymidylate synthase Y261W-dUMP complex'''
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2G8D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8D OCA].
[[Category: Lacticaseibacillus casei]]
[[Category: Lactobacillus casei]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Finer-Moore JS]]
[[Category: Thymidylate synthase]]
[[Category: Stroud RM]]
[[Category: Finer-Moore, J S.]]
[[Category: Stroud, R M.]]
[[Category: active site mutation]]
[[Category: alpha/beta protein]]
[[Category: beta sheet]]
[[Category: dump complex]]
[[Category: methyltransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:13:10 2008''

Latest revision as of 12:26, 14 February 2024

Lactobacillus casei thymidylate synthase Y261W-dUMP complexLactobacillus casei thymidylate synthase Y261W-dUMP complex

Structural highlights

2g8d is a 1 chain structure with sequence from Lacticaseibacillus casei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_LACCA Provides the sole de novo source of dTMP for DNA biosynthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2g8d, resolution 2.40Å

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