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{{Large structure}}
 
==Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2==
==Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2==
<StructureSection load='5it7' size='340' side='right' caption='[[5it7]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<SX load='5it7' size='340' side='right' viewer='molstar' caption='[[5it7]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5it7]] is a 83 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Atcc_56498 Atcc 56498], [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_p283 Saccharomyces cerevisiae p283]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IT7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5it7]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IT7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6EM:(2S)-1-AMINO-N,N,N-TRIMETHYL-1-OXOBUTAN-2-AMINIUM'>6EM</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6EM:(2S)-1-AMINO-N,N,N-TRIMETHYL-1-OXOBUTAN-2-AMINIUM'>6EM</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Eft2, P283_D20866 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1177187 Saccharomyces cerevisiae P283])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5it7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5it7 OCA], [https://pdbe.org/5it7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5it7 RCSB], [https://www.ebi.ac.uk/pdbsum/5it7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5it7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5it7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5it7 OCA], [http://pdbe.org/5it7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5it7 RCSB], [http://www.ebi.ac.uk/pdbsum/5it7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5it7 ProSAT]</span></td></tr>
</table>
</table>
{{Large structure}}
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RSSA_KLULA RSSA_KLULA]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. [[http://www.uniprot.org/uniprot/RS21_KLULA RS21_KLULA]] Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (By similarity). [[http://www.uniprot.org/uniprot/RS27A_KLULA RS27A_KLULA]] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).  Ribosomal protein S27a is a component of the 40S subunit of the ribosome. [[http://www.uniprot.org/uniprot/Q6CW89_KLULA Q6CW89_KLULA]] Ribosomal protein P0 is the functional equivalent of E.coli protein L10.[PIRNR:PIRNR039087] [[http://www.uniprot.org/uniprot/Q6CUW0_KLULA Q6CUW0_KLULA]] Binds to the 23S rRNA.[RuleBase:RU000576]  
[https://www.uniprot.org/uniprot/Q6CQM3_KLULA Q6CQM3_KLULA]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Atcc 56498]]
[[Category: Kluyveromyces lactis]]
[[Category: Kluyveromyces lactis]]
[[Category: Saccharomyces cerevisiae p283]]
[[Category: Large Structures]]
[[Category: Dever, T E]]
[[Category: Dever TE]]
[[Category: Fernandez, I S]]
[[Category: Fernandez IS]]
[[Category: Murray, J]]
[[Category: Murray J]]
[[Category: Ramakrishnan, V]]
[[Category: Ramakrishnan V]]
[[Category: Savva, C G]]
[[Category: Savva CG]]
[[Category: Shin, B S]]
[[Category: Shin BS]]
[[Category: Eef2]]
[[Category: Ire]]
[[Category: Ribosome]]
[[Category: Translocation]]

Latest revision as of 17:08, 30 August 2023

Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2

5it7, resolution 3.60Å

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