5jsa: Difference between revisions

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 ==Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128==
-<StructureSection load='5jsa' size='340' side='right' caption='[[5jsa]], [[Resolution|resolution]] 6.31&Aring;' scene=''>
+<StructureSection load='5jsa' size='340' side='right'caption='[[5jsa]], [[Resolution|resolution]] 6.31&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5jsa]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JSA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5jsa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JSA FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6.308&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5js9|5js9]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jsa OCA], [http://pdbe.org/5jsa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jsa RCSB], [http://www.ebi.ac.uk/pdbsum/5jsa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jsa ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jsa OCA], [https://pdbe.org/5jsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jsa RCSB], [https://www.ebi.ac.uk/pdbsum/5jsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jsa ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447]  The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 22: @@
 ==See Also==
 *[[Antibody 3D structures|Antibody 3D structures]]
-*[[Gp120|Gp120]]
+*[[Gp120 3D structures|Gp120 3D structures]]
-*[[Gp41|Gp41]]
+*[[Gp41 3D Structures|Gp41 3D Structures]]
+*[[3D structures of human antibody|3D structures of human antibody]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Kong, L]]
+[[Category: Human immunodeficiency virus 1]]
-[[Category: Wilson, I A]]
+[[Category: Large Structures]]
-[[Category: Hiv-1 trimer]]
+[[Category: Kong L]]
-[[Category: Sosip]]
+[[Category: Wilson IA]]
-[[Category: Ufo]]
-[[Category: Vaccine]]
-[[Category: Viral protein-immune system complex]]