6cqh: Difference between revisions

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-'''Unreleased structure'''
-The entry 6cqh is ON HOLD
+==Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor==
+<StructureSection load='6cqh' size='340' side='right'caption='[[6cqh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cqh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CQH FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F8Y:(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one'>F8Y</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cqh OCA], [https://pdbe.org/6cqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cqh RCSB], [https://www.ebi.ac.uk/pdbsum/6cqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cqh ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>
-Authors: dos Reis, C.V., de Souza, G.P., Counago, R.M., Azevedo, A., Guimaraes, C., Mascarello, A., Gama, F., Ferreira, M., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-Description: Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Elkins, J.M]]
+__TOC__
-[[Category: Ferreira, M]]
+</StructureSection>
-[[Category: Edwards, A.M]]
+[[Category: Homo sapiens]]
-[[Category: Gama, F]]
+[[Category: Large Structures]]
-[[Category: Arruda, P]]
+[[Category: Arruda P]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Azevedo A]]
-[[Category: Massirer, K.B]]
+[[Category: Counago RM]]
-[[Category: Guimaraes, C]]
+[[Category: Edwards AM]]
-[[Category: Mascarello, A]]
+[[Category: Elkins JM]]
-[[Category: Azevedo, A]]
+[[Category: Ferreira M]]
-[[Category: Counago, R.M]]
+[[Category: Gama F]]
-[[Category: De Souza, G.P]]
+[[Category: Guimaraes C]]
-[[Category: Dos Reis, C.V]]
+[[Category: Mascarello A]]
+[[Category: Massirer KB]]
+[[Category: De Souza GP]]
+[[Category: Dos Reis CV]]