5mr7: Difference between revisions

<StructureSection load='5mr7' size='340' side='right'caption='[[5mr7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[5mr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MR7 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mr7 OCA], [https://pdbe.org/5mr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mr7 RCSB], [https://www.ebi.ac.uk/pdbsum/5mr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mr7 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GRHL2_HUMAN GRHL2_HUMAN] Autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/GRHL2_HUMAN GRHL2_HUMAN] Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293).[UniProtKB:Q8K5C0]<ref>PMID:19015635</ref> <ref>PMID:20938050</ref> <ref>PMID:20978075</ref> <ref>PMID:23254293</ref> <ref>PMID:25152456</ref> <ref>PMID:12175488</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Heinemann U]]

[[Category: Ming Q]]

[[Category: Roske Y]]

[[Category: Schuetz A]]