6f3k: Difference between revisions
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==Combined solid-state NMR, solution-state NMR and EM data for structure determination of the tetrahedral aminopeptidase TET2 from P. horikoshii== | ==Combined solid-state NMR, solution-state NMR and EM data for structure determination of the tetrahedral aminopeptidase TET2 from P. horikoshii== | ||
< | <SX load='6f3k' size='340' side='right' viewer='molstar' caption='[[6f3k]], [[Resolution|resolution]] 4.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6f3k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F3K OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6f3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F3K FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy , Hybrid , Solid-state NMR , Solution NMR, [[Resolution|Resolution]] 4.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f3k OCA], [https://pdbe.org/6f3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f3k RCSB], [https://www.ebi.ac.uk/pdbsum/6f3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f3k ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TET_PYRHO TET_PYRHO] Functions as an aminopeptidase, with a clear preference for leucine as the N-terminal amino acid. However, can also cleave moderately long polypeptide substrates of various compositions in a fairly unspecific manner. Has neither carboxypeptidase nor endoproteolytic activities, and it is devoid of N-terminal deblocking activity. Is involved in protein degradation, performing degradation of oligopeptides produced by the proteasome into single amino acids.<ref>PMID:15375159</ref> <ref>PMID:15713475</ref> <ref>PMID:15736957</ref> | ||
==See Also== | |||
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: Boisbouvier | [[Category: Large Structures]] | ||
[[Category: Colletier | [[Category: Pyrococcus horikoshii OT3]] | ||
[[Category: Effantin | [[Category: Boisbouvier J]] | ||
[[Category: Estrozi | [[Category: Colletier JP]] | ||
[[Category: Favier | [[Category: Effantin G]] | ||
[[Category: Gauto | [[Category: Estrozi LF]] | ||
[[Category: Kerfah | [[Category: Favier A]] | ||
[[Category: Macek | [[Category: Gauto DF]] | ||
[[Category: Schanda | [[Category: Kerfah R]] | ||
[[Category: Schoehn | [[Category: Macek P]] | ||
[[Category: Schwieters | [[Category: Schanda P]] | ||
[[Category: Sivertsen | [[Category: Schoehn G]] | ||
[[Category: Sounier | [[Category: Schwieters CD]] | ||
[[Category: Sivertsen AC]] | |||
[[Category: Sounier R]] | |||