2f8a: Difference between revisions

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-[[Image:2f8a.gif|left|200px]]
- {{Structure
+==Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1==
-|PDB= 2f8a |SIZE=350|CAPTION= <scene name='initialview01'>2f8a</scene>, resolution 1.50&Aring;
+<StructureSection load='2f8a' size='340' side='right'caption='[[2f8a]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>
+<table><tr><td colspan='2'>[[2f8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8A FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-|GENE= GPX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8a OCA], [https://pdbe.org/2f8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8a RCSB], [https://www.ebi.ac.uk/pdbsum/2f8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8a ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8a OCA], [http://www.ebi.ac.uk/pdbsum/2f8a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f8a RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/GPX1_HUMAN GPX1_HUMAN] Protects the hemoglobin in erythrocytes from oxidative breakdown.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8a_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f8a ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1'''
+==See Also==
+*[[Glutathione peroxidase|Glutathione peroxidase]]
+__TOC__
-==Disease==
+</StructureSection>
-Known disease associated with this structure: Hemolytic anemia due to glutathione peroxidase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138320 138320]]
-==About this Structure==
-F8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8A OCA].
-[[Category: Glutathione peroxidase]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Delft, F von.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Gileadi O]]
-[[Category: Gileadi, O.]]
+[[Category: Johansson C]]
-[[Category: Johansson, C.]]
+[[Category: Kavanagh KL]]
-[[Category: Kavanagh, K L.]]
+[[Category: Oppermann U]]
-[[Category: Oppermann, U.]]
+[[Category: Smee C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Sundstrom M]]
-[[Category: Smee, C.]]
+[[Category: Weigelt J]]
-[[Category: Sundstrom, M.]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, C J.]]
-[[Category: sgc]]
-[[Category: structural genomic]]
-[[Category: structural genomics consortium]]
-[[Category: thioredoxin fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:15 2008''