Nuclear receptor corepressor: Difference between revisions
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<StructureSection load='3r2a' size='350' side='right' caption='Structure of human nuclear receptor corepressor 2 SMRT complex with retinoic acid receptor LBD (grey) and the antagonistic ligand Rhein (PDB entry [[3r2a]])' scene=''> | <StructureSection load='3r2a' size='350' side='right' caption='Structure of human nuclear receptor corepressor 2 SMRT (magenta, cyan) complex with retinoic acid receptor LBD (grey, green, pink, yellow) and the antagonistic ligand Rhein (PDB entry [[3r2a]])' scene=''> | ||
== Function == | == Function == | ||
'''Nuclear receptor corepressors''' (N-CoR) and '''SMRT''' (Silencing Mediator of Retinoic acid and Thyroid hormone receptor) mediate the repression of gene subscription by nuclear receptors<ref>PMID:11845213</ref>. | '''Nuclear receptor corepressors''' (N-CoR) and '''SMRT''' (Silencing Mediator of Retinoic acid and Thyroid hormone receptor) mediate the repression of gene subscription by nuclear receptors<ref>PMID:11845213</ref>. N-CoRs contain interaction domains with a conserved LXXII hydrophobic motif. This motif resembles the LXXLL motif of nuclear receptors<ref>PMID:11117528</ref>. | ||
*'''Nuclear receptor corepressor 1''' plays a role in repressing cardiac hypertrophy<ref>PMID:31532577</ref>. | |||
*'''Nuclear receptor corepressor 2''' is part of a multisubunit complex which modify chromatin structure. | |||
== Relevance == | == Relevance == | ||
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*Nuclear receptor corepressor 1 | *Nuclear receptor corepressor 1 | ||
**[[2eqr]] – hN-CoR1 | **[[2eqr]] – hN-CoR1 SANT1 domain 433-486 – human - NMR<br /> | ||
**[[3kmz]] – hN-CoR1 SMRT2 domain + retinoic acid receptor<br /> | **[[3kmz]] – hN-CoR1 SMRT2 domain + retinoic acid receptor<br /> | ||
**[[3n00]] – hN-CoR1 SMRT2 domain + REV-ERBA- | **[[3n00]] – hN-CoR1 SMRT2 domain + REV-ERBA-α<br /> | ||
**[[5x8u]], [[5x8w]] – hN-CoR1 residues 686-700 + protein<br /> | **[[5x8u]], [[5x8w]] – hN-CoR1 residues 686-700 + protein<br /> | ||
**[[3h52]], [[4mdd]] – hN-CoR1 residues 2258-2276 + glucocorticoid receptor + antagonist<br /> | **[[3h52]], [[4mdd]] – hN-CoR1 residues 2258-2276 + glucocorticoid receptor + antagonist<br /> | ||
**[[4wvd]] – hN-CoR1 residues 2258-2276 + bile acid receptor + antagonist<br /> | **[[4wvd]] – hN-CoR1 residues 2258-2276 + bile acid receptor + antagonist<br /> | ||
**[[4y29]] – hN-CoR1 residues 1432-1441 + PPAR- | **[[4y29]] – hN-CoR1 residues 1432-1441 + PPAR-γ + celerythrine<br /> | ||
*Nuclear receptor corepressor 2 | *Nuclear receptor corepressor 2 | ||
**[[2ltp]] – hN-CoR2 SANT2 domain - NMR<br /> | **[[2ltp]] – hN-CoR2 SANT2 domain 615-685 - NMR<br /> | ||
**[[1xc5]] – hN-CoR2 SMRT domain - NMR<br /> | **[[1xc5]] – hN-CoR2 SMRT domain 410-480 - NMR<br /> | ||
**[[6oni]] – hNCOR2 residues 776-798 + PPAR-γ + inhibitor<br /> | |||
**[[6pdz]] – hNCOR2 residues 2318-2339 + PPAR-γ + inhibitor<br /> | |||
**[[4a69]] – hN-CoR2 SMRT domain + histone deacetylase 3 + inositol tetraphosphate<br /> | **[[4a69]] – hN-CoR2 SMRT domain + histone deacetylase 3 + inositol tetraphosphate<br /> | ||
**[[3r2a]] – hN-CoR2 SMRT2 domain + retinoic acid receptor + Rhein<br /> | **[[3r2a]] – hN-CoR2 SMRT2 domain 2346-2361 + retinoic acid receptor + Rhein<br /> | ||
**[[1kkq]] – hN-CoR2 SMRT2 domain + PPAR- | **[[1kkq]] – hN-CoR2 SMRT2 domain + PPAR-α<br /> | ||
**[[5x8x]] – hN-CoR2 SMRT2 domain + protein<br /> | **[[5x8x]] – hN-CoR2 SMRT2 domain + protein<br /> | ||
**[[4oar]] – hN-CoR2 SMRT2 domain + progesterone receptor<br /> | **[[4oar]] – hN-CoR2 SMRT2 domain + progesterone receptor<br /> | ||
**[[2gpv]] – hN-CoR2 SMRT2 domain + estrogen-related receptor- | **[[2gpv]] – hN-CoR2 SMRT2 domain + estrogen-related receptor-γ + tamoxifen<br /> | ||
**[[5x8q]] – hN-CoR2 SMRT2 domain + nuclear receptor ROR- | **[[5x8q]] – hN-CoR2 SMRT2 domain + nuclear receptor ROR-γ + rockogenin<br /> | ||
**[[6a22]], [[6ivx]] – hNCOR2 SMRT2 domain + nuclear receptor ROR-γ + inhibitor<br /> | |||
**[[1r2b]] – hN-CoR2 SMRT residues 1414-1430 + BCL6<br /> | **[[1r2b]] – hN-CoR2 SMRT residues 1414-1430 + BCL6<br /> | ||