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Art:Opening a Gate to Human Health: Difference between revisions

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'''How Ivermectin Works'''
'''How Ivermectin Works'''


In organisms affected by Ivermectin, it causes paralysis and ultimately death. It binds to glutamate-gated chloride channels - proteins in the membranes of nerve and muscle cells which let in chloride ions to pass the signal along. Because Ivermectin binds specifically to channels in invertebrates it leaves the channels in vertebrate cells, such as those in humans, unaffected. It specifically binds to the membrane spanning region (PDB entry [[3RI5]]), causing the channel to be stuck on ‘open’. This leads to increased permeability of chloride ions across the membrane and the inability of the nerves to pass on signals.
In organisms affected by Ivermectin, it causes paralysis and ultimately death. It binds to glutamate-gated chloride channels - proteins in the membranes of nerve and muscle cells which let in chloride ions to pass the signal along. Because Ivermectin binds specifically to channels in invertebrates it leaves the channels in vertebrate cells, such as those in humans, unaffected. It specifically binds to the membrane spanning region (PDB entry [[3ri5]]), causing the channel to be stuck on ‘open’. This leads to increased permeability of chloride ions across the membrane and the inability of the nerves to pass on signals.




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