5no7: Difference between revisions

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 ==Crystal Structure of a Xylan-active Lytic Polysaccharide Monooxygenase from Pycnoporus coccineus.==
-<StructureSection load='5no7' size='340' side='right' caption='[[5no7]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
+<StructureSection load='5no7' size='340' side='right'caption='[[5no7]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5no7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cinnabar-red_polypore Cinnabar-red polypore]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NO7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5no7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trametes_cinnabarina Trametes cinnabarina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NO7 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BN946_scf184298.g17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5643 Cinnabar-red polypore])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5no7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5no7 OCA], [http://pdbe.org/5no7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5no7 RCSB], [http://www.ebi.ac.uk/pdbsum/5no7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5no7 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5no7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5no7 OCA], [https://pdbe.org/5no7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5no7 RCSB], [https://www.ebi.ac.uk/pdbsum/5no7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5no7 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LP14B_TRAC3 LP14B_TRAC3] Lytic polysaccharide monooxygenase (LPMO) that oxidatively cleaves xylan with both C1 and C4 regioselectivity and that specifically targets the protective shield made by heteroxylans that cover cellulose microfibrils in wood (PubMed:29377002, PubMed:32793303). Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate (PubMed:29377002). Cleavage occurs only when xylans are bound to cellulose and not when they are in solution (PubMed:29377002). Increases the efficiency of wood saccharification through oxidative cleavage of highly refractory xylan-coated cellulose fibers via synergistic relationship with xylan-active enzymes, xylobiohydrolases and cellobiohydrolases (PubMed:29377002, PubMed:32793303).<ref>PMID:29377002</ref> <ref>PMID:32793303</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 19: @@
 </div>
 <div class="pdbe-citations 5no7" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Cinnabar-red polypore]]
+[[Category: Large Structures]]
-[[Category: Berrin, J G]]
+[[Category: Trametes cinnabarina]]
-[[Category: Couturier, M]]
+[[Category: Berrin J-G]]
-[[Category: Ladeveze, S]]
+[[Category: Couturier M]]
-[[Category: Sulzenbacher, G]]
+[[Category: Ladeveze S]]
-[[Category: Cellulose]]
+[[Category: Sulzenbacher G]]
-[[Category: Lpmo]]
-[[Category: Oxidoreductase]]
-[[Category: Oxydative enzyme]]
-[[Category: Wood]]
-[[Category: Xylan]]