2e16: Difference between revisions

<StructureSection load='2e16' size='340' side='right'caption='[[2e16]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

== Structural highlights ==

<table><tr><td colspan='2'>[[2e16]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E16 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e16 OCA], [https://pdbe.org/2e16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e16 RCSB], [https://www.ebi.ac.uk/pdbsum/2e16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e16 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e16 TOPSAN]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>

[[Image:Consurf_key_small.gif|200px|right]]

    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/2e16_consurf.spt"</scriptWhenChecked>

    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

    <text>to colour the structure by Evolutionary Conservation</text>

  </jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e16 ConSurf].

<div style="clear:both"></div>

==See Also==

*[[Diphthine synthase|Diphthine synthase]]

<references/>

</StructureSection>

[[Category: Large Structures]]

[[Category: Pyrococcus horikoshii OT3]]

[[Category: Kunishima N]]

[[Category: Matsuura Y]]

[[Category: Mizutani H]]