1lf7: Difference between revisions
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==Crystal Structure of Human Complement Protein C8gamma at 1.2 A Resolution== | ==Crystal Structure of Human Complement Protein C8gamma at 1.2 A Resolution== | ||
<StructureSection load='1lf7' size='340' side='right' caption='[[1lf7]], [[Resolution|resolution]] 1.20Å' scene=''> | <StructureSection load='1lf7' size='340' side='right'caption='[[1lf7]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1lf7]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1lf7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LF7 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lf7 OCA], [https://pdbe.org/1lf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1lf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lf7 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lf/1lf7_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lf/1lf7_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Ginell | [[Category: Large Structures]] | ||
[[Category: Lebioda | [[Category: Ginell S]] | ||
[[Category: Minor | [[Category: Lebioda L]] | ||
[[Category: Ortlund | [[Category: Minor W]] | ||
[[Category: Parker | [[Category: Ortlund E]] | ||
[[Category: Schreck | [[Category: Parker CL]] | ||
[[Category: Sodetz | [[Category: Schreck SF]] | ||
[[Category: Sodetz JM]] | |||