1lf2: Difference between revisions

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OCA

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 ==CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR RS370==
-<StructureSection load='1lf2' size='340' side='right' caption='[[1lf2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='1lf2' size='340' side='right'caption='[[1lf2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1lf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LF2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1lf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LF2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R37:3-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE'>R37</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lfe|1lfe]], [[1lf3|1lf3]], [[1lf4|1lf4]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R37:3-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE'>R37</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lf2 OCA], [https://pdbe.org/1lf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lf2 RCSB], [https://www.ebi.ac.uk/pdbsum/1lf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lf2 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lf2 OCA], [http://pdbe.org/1lf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lf2 RCSB], [http://www.ebi.ac.uk/pdbsum/1lf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lf2 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:11782538, PubMed:15574427, PubMed:8844673). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 14: / Line 15: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lf/1lf2_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 28: / Line 29: @@
 </div>
 <div class="pdbe-citations 1lf2" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Plasmepsin|Plasmepsin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Plafa]]
+[[Category: Large Structures]]
-[[Category: Plasmepsin II]]
-[[Category: Afonina, E]]
-[[Category: Asojo, O A]]
-[[Category: Erickson, J W]]
-[[Category: Gulnik, S V]]
-[[Category: Mehadjed, D]]
-[[Category: Randad, R]]
-[[Category: Silva, A M]]
-[[Category: Yu, B]]
-[[Category: Aspartic protease]]
-[[Category: Hydrolase]]
-[[Category: Plasmepsin]]
 [[Category: Plasmodium falciparum]]
+[[Category: Afonina E]]
+[[Category: Asojo OA]]
+[[Category: Erickson JW]]
+[[Category: Gulnik SV]]
+[[Category: Mehadjed D]]
+[[Category: Randad R]]
+[[Category: Silva AM]]
+[[Category: Yu B]]