5xo2: Difference between revisions

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 ==Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide II==
-<StructureSection load='5xo2' size='340' side='right' caption='[[5xo2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='5xo2' size='340' side='right'caption='[[5xo2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5xo2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XO2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5xo2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_KOS Human alphaherpesvirus 1 strain KOS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XO2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8B9:N-[(2S,3R,4S,6S)-6-(hydroxymethyl)-2,4-bis(oxidanyl)oxan-3-yl]ethanamide'>8B9</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PILRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8B9:2-acetamido-2,4-dideoxy-alpha-D-xylo-hexopyranose'>8B9</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xo2 OCA], [http://pdbe.org/5xo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xo2 RCSB], [http://www.ebi.ac.uk/pdbsum/5xo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xo2 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xo2 OCA], [https://pdbe.org/5xo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xo2 RCSB], [https://www.ebi.ac.uk/pdbsum/5xo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xo2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN]] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref>  [[http://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>
+[https://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Anada, M]]
+[[Category: Human alphaherpesvirus 1 strain KOS]]
-[[Category: Arase, H]]
+[[Category: Large Structures]]
-[[Category: Furukawa, A]]
+[[Category: Anada M]]
-[[Category: Hashimoto, S]]
+[[Category: Arase H]]
-[[Category: Hatori, N]]
+[[Category: Furukawa A]]
-[[Category: Ishizuka, M]]
+[[Category: Hashimoto S]]
-[[Category: Kakita, K]]
+[[Category: Hatori N]]
-[[Category: Kuroki, K]]
+[[Category: Ishizuka M]]
-[[Category: Maeda, N]]
+[[Category: Kakita K]]
-[[Category: Maenaka, K]]
+[[Category: Kuroki K]]
-[[Category: Matsunaga, S]]
+[[Category: Maeda N]]
-[[Category: Nambu, H]]
+[[Category: Maenaka K]]
-[[Category: Nomura, T]]
+[[Category: Matsunaga S]]
-[[Category: Ohsaka, F]]
+[[Category: Nambu H]]
-[[Category: Ose, T]]
+[[Category: Nomura T]]
-[[Category: Saitoh, T]]
+[[Category: Ohsaka F]]
-[[Category: Sakamoto, J]]
+[[Category: Ose T]]
-[[Category: Yamada, T]]
+[[Category: Saitoh T]]
-[[Category: Glycopeptide]]
+[[Category: Sakamoto J]]
-[[Category: Immune receptor]]
+[[Category: Yamada T]]
-[[Category: Immune system]]
-[[Category: Membrane protein]]
-[[Category: Viral entry inhibitor]]