2dml: Difference between revisions

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[[Image:2dml.gif|left|200px]]


{{Structure
==The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6==
|PDB= 2dml |SIZE=350|CAPTION= <scene name='initialview01'>2dml</scene>
<StructureSection load='2dml' size='340' side='right'caption='[[2dml]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DML FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= Pdia6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dml OCA], [https://pdbe.org/2dml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dml RCSB], [https://www.ebi.ac.uk/pdbsum/2dml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dml ProSAT], [https://www.topsan.org/Proteins/RSGI/2dml TOPSAN]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dml OCA], [http://www.ebi.ac.uk/pdbsum/2dml PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dml RCSB]</span>
[https://www.uniprot.org/uniprot/PDIA6_MOUSE PDIA6_MOUSE] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity).
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/2dml_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2DML is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DML OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dml ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein disulfide-isomerase]]
[[Category: Inoue M]]
[[Category: Single protein]]
[[Category: Kigawa T]]
[[Category: Inoue, M.]]
[[Category: Koshiba S]]
[[Category: Kigawa, T.]]
[[Category: Tochio N]]
[[Category: Koshiba, S.]]
[[Category: Yokoyama S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tochio, N.]]
[[Category: Yokoyama, S.]]
[[Category: endoplasmic reticulum]]
[[Category: isomerase]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: redox-active center]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: thioredoxin domain-containing protein 7]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:36:39 2008''

Latest revision as of 21:44, 29 May 2024

The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6

Structural highlights

2dml is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PDIA6_MOUSE May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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