6ffw: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ffw is ON HOLD
+==Phosphotriesterase PTE_A53_5==
+<StructureSection load='6ffw' size='340' side='right'caption='[[6ffw]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ffw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FFW FirstGlance]. <br>
-Description: Phosphotriesterase PTE_A53_5
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D6K:(4~{S},6~{R})-2,2,6-trimethyl-1,3-dioxan-4-ol'>D6K</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fee|6fee]], [[6fef|6fef]], [[6fei|6fei]], [[6fev|6fev]]</td></tr>
-[[Category: Leader, H]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>
-[[Category: Sussman, L.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ffw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffw OCA], [http://pdbe.org/6ffw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ffw RCSB], [http://www.ebi.ac.uk/pdbsum/6ffw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI]] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
+__TOC__
+</StructureSection>
+[[Category: Aryldialkylphosphatase]]
+[[Category: Large Structures]]
+[[Category: Aggarwal, N]]
 [[Category: Albeck, S]]
-[[Category: Unger, T]]
+[[Category: Ashani, Y]]
-[[Category: Aggarwal, N]]
+[[Category: Dym, O]]
+[[Category: Goldsmith, M]]
 [[Category: Greisen, P]]
-[[Category: Goldsmith, M]]
+[[Category: Leader, H]]
-[[Category: Hamer Rogotner, S]]
+[[Category: Rogotner, S Hamer]]
 [[Category: Silman, I]]
+[[Category: Sussman, L J]]
 [[Category: Tawfik, D]]
-[[Category: Ashani, Y]]
+[[Category: Unger, T]]
-[[Category: Dym, O]]
+[[Category: Hydrolase]]
+[[Category: Metalloenzyme]]
+[[Category: Tim barrel]]