1i17: Difference between revisions
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==NMR STRUCTURE OF MOUSE DOPPEL 51-157== | ==NMR STRUCTURE OF MOUSE DOPPEL 51-157== | ||
<StructureSection load='1i17' size='340' side='right' caption='[[1i17 | <StructureSection load='1i17' size='340' side='right'caption='[[1i17]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1i17]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1i17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I17 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i17 OCA], [https://pdbe.org/1i17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i17 RCSB], [https://www.ebi.ac.uk/pdbsum/1i17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i17 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PRND_MOUSE PRND_MOUSE] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/1i17_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/1i17_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1i17" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1i17" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cohen | [[Category: Mus musculus]] | ||
[[Category: Dyson | [[Category: Cohen FE]] | ||
[[Category: Mo | [[Category: Dyson HJ]] | ||
[[Category: Moore | [[Category: Mo H]] | ||
[[Category: Prusiner | [[Category: Moore RC]] | ||
[[Category: Westaway | [[Category: Prusiner SB]] | ||
[[Category: Wright | [[Category: Westaway D]] | ||
[[Category: Wright PE]] | |||
Latest revision as of 09:43, 30 October 2024
NMR STRUCTURE OF MOUSE DOPPEL 51-157NMR STRUCTURE OF MOUSE DOPPEL 51-157
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe downstream prion-like protein (doppel, or Dpl) is a paralog of the cellular prion protein, PrP(C). The two proteins have approximately 25% sequence identity, but seem to have distinct physiologic roles. Unlike PrP(C), Dpl does not support prion replication; instead, overexpression of Dpl in the brain seems to cause a completely different neurodegenerative disease. We report the solution structure of a fragment of recombinant mouse Dpl (residues 26-157) containing a globular domain with three helices and a small amount of beta-structure. Overall, the topology of Dpl is very similar to that of PrP(C). Significant differences include a marked kink in one of the helices in Dpl, and a different orientation of the two short beta-strands. Although the two proteins most likely arose through duplication of a single ancestral gene, the relationship is now so distant that only the structures retain similarity; the functions have diversified along with the sequence. Two different neurodegenerative diseases caused by proteins with similar structures.,Mo H, Moore RC, Cohen FE, Westaway D, Prusiner SB, Wright PE, Dyson HJ Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2352-7. PMID:11226243[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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