Liver X receptor: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='liver X receptpr' scene=''> == Function == liver X receptpr (LXR) <ref>PMID:12906827</ref> == Disease == == Relevance ==... |
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<StructureSection load='' size='350' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'> | |||
== Function == | |||
'''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | |||
*'''Liver X receptor alpha''' has a role in regulating innate immunity at the genomic level. | |||
*'''Liver X receptor beta''' is an important transcription factor promoting the survival of single-positive thymocytes<ref>PMID:32963358</ref>. | |||
See also [[Intracellular receptors]] | |||
== Disease == | == Disease == | ||
Treatment of mice demonstrating Wilson disease with LXR agonist reduced disease manifestations without worsening neurological symptoms associated with the conventional therapy based on copper chelation<ref>PMID:26679751</ref>. | |||
== Relevance == | == Relevance == | ||
LXRs have emerged as promising drug targets for anti-atherosclerotic therapies<ref>PMID:20363253</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
<scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR <scene name='77/776388/Cv/4'>modulator binds to the LXR</scene> in the LXR/retinoic X receptor β heterodimer in a hydrophobic <scene name='77/776388/Cv/5'>pocket</scene><ref>PMID:27599745</ref>. | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of liver X | == 3D Structures of liver X receptor == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
* Liver X receptor | * Liver X receptor α | ||
**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist - human<br /> | |||
**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist<br /> | **[[1uhl]] – hLXR LBD + retinoic X receptor β + NCOA-2 <br /> | ||
**[[1uhl]] – hLXR LBD + retinoic X receptor | **[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br /> | ||
* Liver X receptor | * Liver X receptor β | ||
**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]] – hLXR LBD + agonist – | **[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]], [[6s4n]], [[6s4t]], [[6s4u]], [[6s5k]] – hLXR LBD + agonist<br /> | ||
**[[6k9g]], [[6k9h]], [[6k9m]] – hLXR LBD (mutant) + agonist <br /> | |||
**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br /> | **[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br /> | ||
**[[5i4v]] – hLXR LBD + retinoic X receptor | **[[6jio]] – hLXR LBD (mutant) + ligand<br /> | ||
**[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor | **[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br /> | ||
**[[3fal]] – hLXR LBD + retinoic X receptor | **[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br /> | ||
**[[5hjp]] – hLXR LBD + retinoic X receptor | **[[3fal]] – hLXR LBD + retinoic X receptor β + modulator + retinoic acid<br /> | ||
**[[4nqa]] – hLXR LBD + retinoic X receptor | **[[5hjp]] – hLXR LBD + retinoic X receptor β + agonist<br /> | ||
**[[4dk7]], [[4dk8]] – hLXR LBD + NCOA-1 peptide + agonist<br /> | **[[4nqa]] – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA <br /> | ||
**[[4dk7]], [[4dk8]], [[5avi]] – hLXR LBD + NCOA-1 peptide + agonist<br /> | |||
**[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br /> | **[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br /> | ||
**[[3l0e]] – hLXR LBD + NCOA-2 peptide + inhibitor<br /> | |||
}} | }} | ||
== References == | == References == | ||