1e52: Difference between revisions
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==Solution structure of Escherichia coli UvrB C-terminal domain== | ==Solution structure of Escherichia coli UvrB C-terminal domain== | ||
<StructureSection load='1e52' size='340' side='right' caption='[[1e52 | <StructureSection load='1e52' size='340' side='right'caption='[[1e52]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1e52]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1e52]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E52 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e52 OCA], [https://pdbe.org/1e52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e52 RCSB], [https://www.ebi.ac.uk/pdbsum/1e52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e52 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/UVRB_ECOLI UVRB_ECOLI] The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.<ref>PMID:12145219</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</div> | </div> | ||
<div class="pdbe-citations 1e52" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1e52" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[UvrABC 3D structures|UvrABC 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Alexandrovich | [[Category: Large Structures]] | ||
[[Category: Frenkiel | [[Category: Alexandrovich AA]] | ||
[[Category: Goosen | [[Category: Frenkiel TA]] | ||
[[Category: Kelly | [[Category: Goosen NN]] | ||
[[Category: Lane | [[Category: Kelly GG]] | ||
[[Category: Moolenaar | [[Category: Lane AN]] | ||
[[Category: Sanderson | [[Category: Moolenaar GF]] | ||
[[Category: Sanderson MR]] | |||