6f6y: Difference between revisions

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-'''Unreleased structure'''
-The entry 6f6y is ON HOLD
+==Crystal structure of galectin-3 CRD in complex with galactopentaose==
+<StructureSection load='6f6y' size='340' side='right' caption='[[6f6y]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
-Authors: Hakansson, M., Andersen, M.C.F., Clausen, M.H., Logan, D.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6f6y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F6Y FirstGlance]. <br>
-Description: Crystal structure of galectin-3 CRD in complex with galactopentaose
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f6y OCA], [http://pdbe.org/6f6y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f6y RCSB], [http://www.ebi.ac.uk/pdbsum/6f6y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f6y ProSAT]</span></td></tr>
-[[Category: Logan, D.T]]
+</table>
-[[Category: Clausen, M.H]]
+== Function ==
-[[Category: Andersen, M.C.F]]
+[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Andersen, M C.F]]
+[[Category: Clausen, M H]]
 [[Category: Hakansson, M]]
+[[Category: Logan, D T]]
+[[Category: Carbohydrate recognition]]
+[[Category: Galectin]]
+[[Category: Sugar binding protein]]