5wo4: Difference between revisions

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==JAK1 complexed with compound 28==
==JAK1 complexed with compound 28==
<StructureSection load='5wo4' size='340' side='right' caption='[[5wo4]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='5wo4' size='340' side='right'caption='[[5wo4]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5wo4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WO4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5wo4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WO4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B7V:3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]-1H-pyrazole-4-carboxamide'>B7V</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7V:3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]-1H-pyrazole-4-carboxamide'>B7V</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wo4 OCA], [https://pdbe.org/5wo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wo4 RCSB], [https://www.ebi.ac.uk/pdbsum/5wo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wo4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wo4 OCA], [http://pdbe.org/5wo4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wo4 RCSB], [http://www.ebi.ac.uk/pdbsum/5wo4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wo4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.  
[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wo4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wo4" style="background-color:#fffaf0;"></div>
==See Also==
*[[Janus kinase 3D structures|Janus kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Homo sapiens]]
[[Category: Lesburg, C A]]
[[Category: Large Structures]]
[[Category: Patel, S B]]
[[Category: Lesburg CA]]
[[Category: Protein tyrosine kinase]]
[[Category: Patel SB]]
[[Category: Transferase]]

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