2mev: Difference between revisions

<StructureSection load='2mev' size='340' side='right' caption='[[2mev]], [[Resolution|resolution]] 3.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[2mev]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enmgo Enmgo]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mev 1mev]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MEV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MEV FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mev OCA], [http://pdbe.org/2mev PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mev RCSB], [http://www.ebi.ac.uk/pdbsum/2mev PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mev ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/POLG_ENMGO POLG_ENMGO]] Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes (By similarity).  Protein VP0: VP0 precursor is a component of immature procapsids (By similarity).  Protein 2B: Affects membrane integrity and cause an increase in membrane permeability (By similarity).  Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).  Protein 3A, via its hydrophobic domain, serves as membrane anchor (By similarity).  Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity).  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).  Protein 2A: is involved in host translation shutoff. Nuclear localization is required for this function (By similarity).  

     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/2mev_consurf.spt"</scriptWhenChecked>

[[Category: Enmgo]]

[[Category: Rossmann, M G]]

[[Category: Icosahedral virus]]

[[Category: Virus]]