5m7c: Difference between revisions

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==Blood group synthase AAGlyB in complex with UDP and cryoprotected with PEG 3350==
==Blood group synthase AAGlyB in complex with UDP and cryoprotected with PEG 3350==
<StructureSection load='5m7c' size='340' side='right' caption='[[5m7c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5m7c' size='340' side='right'caption='[[5m7c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5m7c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M7C FirstGlance]. <br>
<table><tr><td colspan='2'>[[5m7c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M7C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zgf|3zgf]], [[3zgg|3zgg]], [[5m79|5m79]], [[5m7a|5m7a]], [[5m7b|5m7b]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7c OCA], [http://pdbe.org/5m7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m7c RCSB], [http://www.ebi.ac.uk/pdbsum/5m7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7c OCA], [https://pdbe.org/5m7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m7c RCSB], [https://www.ebi.ac.uk/pdbsum/5m7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.  
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
 
==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Rocha, J]]
[[Category: Homo sapiens]]
[[Category: Royant, A]]
[[Category: Large Structures]]
[[Category: Blood group synthase]]
[[Category: Rocha J]]
[[Category: Cis-ab mutant]]
[[Category: Royant A]]
[[Category: Dual-specificity]]
[[Category: Glycosyltransferase]]
[[Category: Transferase]]

Latest revision as of 21:28, 1 November 2023

Blood group synthase AAGlyB in complex with UDP and cryoprotected with PEG 3350Blood group synthase AAGlyB in complex with UDP and cryoprotected with PEG 3350

Structural highlights

5m7c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BGAT_HUMAN This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

See Also

5m7c, resolution 1.60Å

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