5f91: Difference between revisions
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==Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator (N-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)== | ==Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator (N-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)== | ||
<StructureSection load='5f91' size='340' side='right' caption='[[5f91]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='5f91' size='340' side='right'caption='[[5f91]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5f91]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5f91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F91 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5WJ:~{N}-[5-(AZEPAN-1-YLSULFONYL)-2-METHOXY-PHENYL]-2-(4-OXIDANYLIDENE-3~{H}-PHTHALAZIN-1-YL)ETHANAMIDE'>5WJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.998Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5WJ:~{N}-[5-(AZEPAN-1-YLSULFONYL)-2-METHOXY-PHENYL]-2-(4-OXIDANYLIDENE-3~{H}-PHTHALAZIN-1-YL)ETHANAMIDE'>5WJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f91 OCA], [https://pdbe.org/5f91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f91 RCSB], [https://www.ebi.ac.uk/pdbsum/5f91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f91 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FUMC_MYCTU FUMC_MYCTU] Catalyzes the reversible addition of water to fumarate to give L-malate. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5f91" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5f91" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Fumarase|Fumarase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis CDC1551]] | ||
[[Category: Abell | [[Category: Abell C]] | ||
[[Category: Barry | [[Category: Barry CE]] | ||
[[Category: Boshoff | [[Category: Boshoff HI]] | ||
[[Category: Fischer | [[Category: Fischer G]] | ||
[[Category: Hyvonen | [[Category: Hyvonen M]] | ||
[[Category: Kasbekar | [[Category: Kasbekar M]] | ||
[[Category: Mott | [[Category: Mott BT]] | ||
[[Category: Thomas | [[Category: Thomas CJ]] | ||
[[Category: Yasgar | [[Category: Yasgar A]] | ||