4pl4: Difference between revisions

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 ==Crystal structure of murine IRE1 in complex with OICR464 inhibitor==
-<StructureSection load='4pl4' size='340' side='right' caption='[[4pl4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='4pl4' size='340' side='right'caption='[[4pl4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pl3|4pl3]], [[4pl5|4pl5]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ern1, Ire1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [https://pdbe.org/4pl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://pdbe.org/4pl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE]] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref>
+[https://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 19: @@
 </div>
 <div class="pdbe-citations 4pl4" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ire1|Ire1]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Al-awar, R]]
+[[Category: Mus musculus]]
-[[Category: Chiovitti, D]]
+[[Category: Al-awar R]]
-[[Category: Duffy, N]]
+[[Category: Chiovitti D]]
-[[Category: Patterson, J B]]
+[[Category: Duffy N]]
-[[Category: Sanches, M]]
+[[Category: Patterson JB]]
-[[Category: Sicheri, F]]
+[[Category: Sanches M]]
-[[Category: Talukdar, M]]
+[[Category: Sicheri F]]
-[[Category: Thevakumaran, N]]
+[[Category: Talukdar M]]
-[[Category: Endoribonuclease]]
+[[Category: Thevakumaran N]]
-[[Category: Hydrolase-inhibitor complex]]
-[[Category: Inhibitor complex]]
-[[Category: Schiff base]]
-[[Category: Transferase]]
-[[Category: Unfolded protein response]]