4z7i: Difference between revisions
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==Crystal structure of insulin regulated aminopeptidase in complex with ligand== | ==Crystal structure of insulin regulated aminopeptidase in complex with ligand== | ||
<StructureSection load='4z7i' size='340' side='right' caption='[[4z7i]], [[Resolution|resolution]] 3.31Å' scene=''> | <StructureSection load='4z7i' size='340' side='right'caption='[[4z7i]], [[Resolution|resolution]] 3.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4z7i]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4z7i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z7I FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.31Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2X0:[(1R)-1-AMINO-3-PHENYLPROPYL]PHOSPHONIC+ACID'>2X0</scene>, <scene name='pdbligand=4L8:(2R)-2-(AMINOMETHYL)-4-METHYLPENTANOIC+ACID'>4L8</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z7i OCA], [https://pdbe.org/4z7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z7i RCSB], [https://www.ebi.ac.uk/pdbsum/4z7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z7i ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/LCAP_HUMAN LCAP_HUMAN] Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.<ref>PMID:11389728</ref> <ref>PMID:11707427</ref> <ref>PMID:1731608</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4z7i" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4z7i" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Harlos | [[Category: Synthetic construct]] | ||
[[Category: Mpakali | [[Category: Harlos K]] | ||
[[Category: Saridakis | [[Category: Mpakali A]] | ||
[[Category: Stratikos | [[Category: Saridakis E]] | ||
[[Category: Zhao | [[Category: Stratikos E]] | ||
[[Category: Zhao Y]] | |||