3jad: Difference between revisions
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==Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, strychnine-bound state== | ==Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, strychnine-bound state== | ||
< | <SX load='3jad' size='340' side='right' viewer='molstar' caption='[[3jad]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3jad]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3jad]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. The November 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Glutamate-gated Chloride Receptors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_11 10.2210/rcsb_pdb/mom_2015_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JAD FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jad OCA], [https://pdbe.org/3jad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jad RCSB], [https://www.ebi.ac.uk/pdbsum/3jad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jad ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GLRA1_DANRE GLRA1_DANRE] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).[UniProtKB:P23415]<ref>PMID:10188956</ref> <ref>PMID:26344198</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: | [[Category: Danio rerio]] | ||
[[Category: Glutamate-gated Chloride Receptors]] | [[Category: Glutamate-gated Chloride Receptors]] | ||
[[Category: Large Structures]] | |||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Cheng | [[Category: Cheng YF]] | ||
[[Category: Du | [[Category: Du J]] | ||
[[Category: Gouaux | [[Category: Gouaux E]] | ||
[[Category: Lu | [[Category: Lu W]] | ||
[[Category: Wu | [[Category: Wu SP]] | ||