2awt: Difference between revisions

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-[[Image:2awt.jpg|left|200px]]
- {{Structure
+==Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)==
-|PDB= 2awt |SIZE=350|CAPTION= <scene name='initialview01'>2awt</scene>
+<StructureSection load='2awt' size='340' side='right'caption='[[2awt]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2awt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWT FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awt OCA], [https://pdbe.org/2awt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awt RCSB], [https://www.ebi.ac.uk/pdbsum/2awt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awt ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=[[1wm2|1WM2]], [[1wm3|1WM3]]
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2awt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awt OCA], [http://www.ebi.ac.uk/pdbsum/2awt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2awt RCSB]</span>
+[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/2awt_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2awt ConSurf].
+<div style="clear:both"></div>
-'''Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)'''
+==See Also==
+*[[SUMO 3D Structures|SUMO 3D Structures]]
+== References ==
-==About this Structure==
+<references/>
-AWT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWT OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Chang, C F.]]
+[[Category: Chang CF]]
-[[Category: Chang, C K.]]
+[[Category: Chang CK]]
-[[Category: Chung, T L.]]
+[[Category: Chung TL]]
-[[Category: Huang, T H.]]
+[[Category: Huang TH]]
-[[Category: Li, S S.L.]]
+[[Category: Li SSL]]
-[[Category: Wang, Y H.]]
+[[Category: Wang YH]]
-[[Category: half-open barrel]]
-[[Category: two helice]]
-[[Category: ubiquitin fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:58:17 2008''