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==Atomic Model of the SRP-FtsY Early Conformation==
==Atomic Model of the SRP-FtsY Early Conformation==
<StructureSection load='2xkv' size='340' side='right' caption='[[2xkv]], [[Resolution|resolution]] 13.50&Aring;' scene=''>
<SX load='2xkv' size='340' side='right' viewer='molstar' caption='[[2xkv]], [[Resolution|resolution]] 13.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xkv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKV FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKV FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j28|2j28]], [[2j7p|2j7p]], [[1jpj|1jpj]], [[1ng1|1ng1]], [[2cnw|2cnw]], [[2c03|2c03]], [[1dul|1dul]], [[2ng1|2ng1]], [[1ls1|1ls1]], [[1o87|1o87]], [[1ry1|1ry1]], [[1jpn|1jpn]], [[2j45|2j45]], [[2j46|2j46]], [[1rj9|1rj9]], [[1ffh|1ffh]], [[1hq1|1hq1]], [[2ffh|2ffh]], [[2c04|2c04]], [[2iyl|2iyl]], [[1okk|1okk]], [[2iy3|2iy3]], [[3ng1|3ng1]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 13.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Signal-recognition-particle_GTPase Signal-recognition-particle GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.4 3.6.5.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkv OCA], [https://pdbe.org/2xkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkv RCSB], [https://www.ebi.ac.uk/pdbsum/2xkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkv OCA], [http://pdbe.org/2xkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkv RCSB], [http://www.ebi.ac.uk/pdbsum/2xkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity). [[http://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306] [[http://www.uniprot.org/uniprot/SRP54_ECOLI SRP54_ECOLI]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:2171778</ref> <ref>PMID:1279430</ref> <ref>PMID:1331806</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15140892</ref> 
[https://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2xkv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2xkv" style="background-color:#fffaf0;"></div>
==See Also==
*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
*[[Signal recognition particle receptor 3D structures|Signal recognition particle receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Signal-recognition-particle GTPase]]
[[Category: Large Structures]]
[[Category: Ban, N]]
[[Category: Ban N]]
[[Category: Boehringer, D]]
[[Category: Boehringer D]]
[[Category: Estrozi, L F]]
[[Category: Estrozi LF]]
[[Category: Schaffitzel, C]]
[[Category: Schaffitzel C]]
[[Category: Shan, S o]]
[[Category: Shan S-o]]
[[Category: Protein transport]]

Latest revision as of 13:27, 9 May 2024

Atomic Model of the SRP-FtsY Early ConformationAtomic Model of the SRP-FtsY Early Conformation

2xkv, resolution 13.50Å

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