4kh6: Difference between revisions

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 ==Toxoplasma gondii NTPDase1 C258S/C268S E493G crystallized with Mg and AMPNP==
-<StructureSection load='4kh6' size='340' side='right' caption='[[4kh6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='4kh6' size='340' side='right'caption='[[4kh6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4kh6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KH6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4kh6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KH6 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU1:5-O-[(R)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]ADENOSINE'>AU1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a57|4a57]], [[4a59|4a59]], [[4a5a|4a5a]], [[4a5b|4a5b]], [[4jep|4jep]], [[4kh4|4kh4]], [[4kh5|4kh5]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU1:5-O-[(R)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]ADENOSINE'>AU1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NTP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kh6 OCA], [https://pdbe.org/4kh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4kh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kh6 ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphatase Nucleoside-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.15 3.6.1.15] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kh6 OCA], [http://pdbe.org/4kh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kh6 RCSB], [http://www.ebi.ac.uk/pdbsum/4kh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kh6 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
+[https://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 4kh6" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ectonucleoside triphosphate diphosphohydrolase|Ectonucleoside triphosphate diphosphohydrolase]]
+*[[Nucleoside triphosphatase|Nucleoside triphosphatase]]
+*[[Sandbox 30008|Sandbox 30008]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Nucleoside-triphosphatase]]
+[[Category: Large Structures]]
-[[Category: Toxgo]]
+[[Category: Toxoplasma gondii]]
-[[Category: Krug, U]]
+[[Category: Krug U]]
-[[Category: Strater, N]]
+[[Category: Strater N]]
-[[Category: Totzauer, R]]
+[[Category: Totzauer R]]
-[[Category: Actin-like fold]]
-[[Category: Hydrolase]]
-[[Category: Ntpdase]]