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==Crystal structure of Ubc7p in complex with the U7BR of Cue1p==
==Crystal structure of Ubc7p in complex with the U7BR of Cue1p==
<StructureSection load='4jqu' size='340' side='right' caption='[[4jqu]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
<StructureSection load='4jqu' size='340' side='right'caption='[[4jqu]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JQU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JQU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">QRI8, UBC7, Ubc7p, YM9711.12, YMR022W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CUE1, Cue1p, KIS4, YM8156.06, YMR264W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqu OCA], [https://pdbe.org/4jqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jqu RCSB], [https://www.ebi.ac.uk/pdbsum/4jqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jqu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqu OCA], [http://pdbe.org/4jqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jqu RCSB], [http://www.ebi.ac.uk/pdbsum/4jqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jqu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UBC7_YEAST UBC7_YEAST]] Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Involved in resistance to cadmium poisoning.<ref>PMID:8393731</ref> <ref>PMID:9388185</ref> <ref>PMID:9695950</ref> <ref>PMID:11641273</ref> <ref>PMID:11390656</ref> <ref>PMID:11146622</ref> <ref>PMID:16873066</ref> [[http://www.uniprot.org/uniprot/CUE1_YEAST CUE1_YEAST]] Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has also a role in cold adaptation, perhaps through effects on sterol biosynthesis.<ref>PMID:9388185</ref> <ref>PMID:9335582</ref> <ref>PMID:10991948</ref> <ref>PMID:10982838</ref> <ref>PMID:10878801</ref> <ref>PMID:11406589</ref> <ref>PMID:11390656</ref> <ref>PMID:12399372</ref> <ref>PMID:16873066</ref> <ref>PMID:16607018</ref> <ref>PMID:16556771</ref> 
[https://www.uniprot.org/uniprot/UBC7_YEAST UBC7_YEAST] Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Involved in resistance to cadmium poisoning.<ref>PMID:8393731</ref> <ref>PMID:9388185</ref> <ref>PMID:9695950</ref> <ref>PMID:11641273</ref> <ref>PMID:11390656</ref> <ref>PMID:11146622</ref> <ref>PMID:16873066</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jqu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jqu" style="background-color:#fffaf0;"></div>
==See Also==
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Ji, X]]
[[Category: Ji X]]
[[Category: Liang, Y H]]
[[Category: Liang Y-H]]
[[Category: Metzger, M B]]
[[Category: Metzger MB]]
[[Category: Weissman, A M]]
[[Category: Weissman AM]]
[[Category: Ligase-activator complex]]
[[Category: Ligase-protein binding complex]]
[[Category: Ubc7p:u7br complex]]

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