3sm9: Difference between revisions
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==Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist== | ==Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist== | ||
<StructureSection load='3sm9' size='340' side='right' caption='[[3sm9]], [[Resolution|resolution]] 2.26Å' scene=''> | <StructureSection load='3sm9' size='340' side='right'caption='[[3sm9]], [[Resolution|resolution]] 2.26Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3sm9]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3sm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SM9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sm9 OCA], [https://pdbe.org/3sm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3sm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sm9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref> | ||
==See Also== | |||
*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Cossar | [[Category: Bountra C]] | ||
[[Category: Crombet | [[Category: Cossar D]] | ||
[[Category: Dobrovetsky | [[Category: Crombet L]] | ||
[[Category: Dong | [[Category: Dobrovetsky E]] | ||
[[Category: Edwards | [[Category: Dong A]] | ||
[[Category: Khutoreskaya | [[Category: Edwards AM]] | ||
[[Category: Khutoreskaya G]] | |||
[[Category: Seitova | [[Category: Seitova A]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Wernimont | [[Category: Wernimont AK]] | ||