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==Crystal Structure of PriB Binary Complex with Product Diphosphate==
==Crystal Structure of PriB Binary Complex with Product Diphosphate==
<StructureSection load='5k9m' size='340' side='right' caption='[[5k9m]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='5k9m' size='340' side='right'caption='[[5k9m]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5k9m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._rm-5-8 Streptomyces sp. rm-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K9M FirstGlance]. <br>
<table><tr><td colspan='2'>[[5k9m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._RM-5-8 Streptomyces sp. RM-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K9M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5inj|5inj]], [[5jxm|5jxm]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k9m OCA], [http://pdbe.org/5k9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k9m RCSB], [http://www.ebi.ac.uk/pdbsum/5k9m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k9m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k9m OCA], [https://pdbe.org/5k9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k9m RCSB], [https://www.ebi.ac.uk/pdbsum/5k9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k9m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A182DWE5_9ACTN A0A182DWE5_9ACTN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces sp. rm-5-8]]
[[Category: Large Structures]]
[[Category: Benach, J]]
[[Category: Streptomyces sp. RM-5-8]]
[[Category: Cao, H]]
[[Category: Benach J]]
[[Category: Elshahawi, S]]
[[Category: Cao H]]
[[Category: Koss, J W]]
[[Category: Elshahawi S]]
[[Category: Morisco, L L]]
[[Category: Koss JW]]
[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
[[Category: Morisco LL]]
[[Category: Phillips, G N]]
[[Category: Phillips Jr GN]]
[[Category: Thorson, J S]]
[[Category: Thorson JS]]
[[Category: Wasserman, S R]]
[[Category: Wasserman SR]]
[[Category: Abba family]]
[[Category: Diphosphate]]
[[Category: Enzyme discovery for natural product biosynthesis]]
[[Category: Indole-pt]]
[[Category: Natpro]]
[[Category: Prenyltransferase]]
[[Category: PSI, Protein structure initiative]]
[[Category: Pt fold]]
[[Category: Structural genomic]]
[[Category: Transferase]]

Latest revision as of 12:56, 27 September 2023

Crystal Structure of PriB Binary Complex with Product DiphosphateCrystal Structure of PriB Binary Complex with Product Diphosphate

Structural highlights

5k9m is a 1 chain structure with sequence from Streptomyces sp. RM-5-8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A182DWE5_9ACTN

Publication Abstract from PubMed

This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.

Structure and specificity of a permissive bacterial C-prenyltransferase.,Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S Nat Chem Biol. 2017 Feb 6. doi: 10.1038/nchembio.2285. PMID:28166207[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S. Structure and specificity of a permissive bacterial C-prenyltransferase. Nat Chem Biol. 2017 Feb 6. doi: 10.1038/nchembio.2285. PMID:28166207 doi:http://dx.doi.org/10.1038/nchembio.2285

5k9m, resolution 1.50Å

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