4tk2: Difference between revisions

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==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61==
==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P61==
<StructureSection load='4tk2' size='340' side='right' caption='[[4tk2]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<StructureSection load='4tk2' size='340' side='right'caption='[[4tk2]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4tk2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TK2 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fu3|2fu3]], [[2fts|2fts]], [[4pdo|4pdo]], [[4pd1|4pd1]], [[4tk1|4tk1]], [[4tk3|4tk3]], [[4tk4|4tk4]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gphn, Gph ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [https://pdbe.org/4tk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk2 OCA], [http://pdbe.org/4tk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tk2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
[https://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4tk2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4tk2" style="background-color:#fffaf0;"></div>
==See Also==
*[[Gephyrin|Gephyrin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Kasaragod, V B]]
[[Category: Rattus norvegicus]]
[[Category: Maric, H M]]
[[Category: Kasaragod VB]]
[[Category: Schindelin, H]]
[[Category: Maric HM]]
[[Category: Biosynthetic protein]]
[[Category: Schindelin H]]
[[Category: Molybdenum co factor biosynthesis]]
[[Category: Neurotransmitter receptor anchoring]]
[[Category: Scaffolding protein]]
[[Category: Structural protein]]

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