3ga2: Difference between revisions

No edit summary
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624==
==Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624==
<StructureSection load='3ga2' size='340' side='right' caption='[[3ga2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3ga2' size='340' side='right'caption='[[3ga2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ga2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GA2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ga2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GA2 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribonuclease_V Deoxyribonuclease V], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.7 3.1.21.7] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ga2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga2 OCA], [http://pdbe.org/3ga2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ga2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ga2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga2 ProSAT], [http://www.topsan.org/Proteins/NESGC/3ga2 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ga2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga2 OCA], [https://pdbe.org/3ga2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ga2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ga2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga2 ProSAT], [https://www.topsan.org/Proteins/NESGC/3ga2 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NFI_BACSU NFI_BACSU]] Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity).  
[https://www.uniprot.org/uniprot/NFI_BACSU NFI_BACSU] Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga2_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga2_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ga2 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ga2 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibrio subtilis ehrenberg 1835]]
[[Category: Bacillus subtilis]]
[[Category: Deoxyribonuclease V]]
[[Category: Large Structures]]
[[Category: Abashidze, M]]
[[Category: Abashidze M]]
[[Category: Acton, T B]]
[[Category: Acton TB]]
[[Category: Cunningham, K]]
[[Category: Cunningham K]]
[[Category: Everett, J K]]
[[Category: Everett JK]]
[[Category: Fang, Y]]
[[Category: Fang Y]]
[[Category: Forouhar, F]]
[[Category: Forouhar F]]
[[Category: Hunt, J F]]
[[Category: Hunt JF]]
[[Category: Hussain, M]]
[[Category: Hussain M]]
[[Category: Janjua, H]]
[[Category: Janjua H]]
[[Category: Ma, L-.C]]
[[Category: Ma L-C]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Nair R]]
[[Category: Nair, R]]
[[Category: Owens L]]
[[Category: Owens, L]]
[[Category: Rost B]]
[[Category: Rost, B]]
[[Category: Seetharaman J]]
[[Category: Seetharaman, J]]
[[Category: Tong L]]
[[Category: Tong, L]]
[[Category: Wang D]]
[[Category: Wang, D]]
[[Category: Xiao R]]
[[Category: Xiao, R]]
[[Category: Alpha-beta protein]]
[[Category: Cytoplasm]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Magnesium]]
[[Category: Nesg]]
[[Category: Nuclease]]
[[Category: PSI, Protein structure initiative]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA