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==Human Acyl-coenzyme A thioesterase 12==
==Human Acyl-coenzyme A thioesterase 12==
<StructureSection load='3b7k' size='340' side='right' caption='[[3b7k]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3b7k' size='340' side='right'caption='[[3b7k]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3b7k]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B7K FirstGlance]. <br>
<table><tr><td colspan='2'>[[3b7k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT12, CACH, CACH1, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_hydrolase Acetyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.1 3.1.2.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7k OCA], [https://pdbe.org/3b7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7k RCSB], [https://www.ebi.ac.uk/pdbsum/3b7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7k OCA], [http://pdbe.org/3b7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b7k RCSB], [http://www.ebi.ac.uk/pdbsum/3b7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACO12_HUMAN ACO12_HUMAN]] Hydrolyzes acetyl-CoA to acetate and CoA.<ref>PMID:16951743</ref>
[https://www.uniprot.org/uniprot/ACO12_HUMAN ACO12_HUMAN] Hydrolyzes acetyl-CoA to acetate and CoA.<ref>PMID:16951743</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/3b7k_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/3b7k_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 21: Line 20:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b7k ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b7k ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acetyl-CoA hydrolase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Berg, S Van Den]]
[[Category: Berglund H]]
[[Category: Berglund, H]]
[[Category: Busam RD]]
[[Category: Busam, R D]]
[[Category: Collins R]]
[[Category: Collins, R]]
[[Category: Dahlgren LG]]
[[Category: Dahlgren, L G]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Flodin S]]
[[Category: Flodin, S]]
[[Category: Flores A]]
[[Category: Flores, A]]
[[Category: Graslund S]]
[[Category: Graslund, S]]
[[Category: Hallberg BM]]
[[Category: Hallberg, B M]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M]]
[[Category: Herman MD]]
[[Category: Herman, M D]]
[[Category: Johansson A]]
[[Category: Johansson, A]]
[[Category: Johansson I]]
[[Category: Johansson, I]]
[[Category: Kallas A]]
[[Category: Kallas, A]]
[[Category: Karlberg T]]
[[Category: Karlberg, T]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T]]
[[Category: Lehtio L]]
[[Category: L., Svensson]]
[[Category: Moche M]]
[[Category: Lehtio, L]]
[[Category: Nilsson ME]]
[[Category: Moche, M]]
[[Category: Nordlund P]]
[[Category: Nilsson, M E]]
[[Category: Nyman T]]
[[Category: Nordlund, P]]
[[Category: Persson C]]
[[Category: Nyman, T]]
[[Category: Sagemark J]]
[[Category: Persson, C]]
[[Category: Sundstrom M]]
[[Category: Structural genomic]]
[[Category: Svensson L]]
[[Category: Sagemark, J]]
[[Category: Thorsell AG]]
[[Category: Sundstrom, M]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G]]
[[Category: Van Den Berg S]]
[[Category: Tresaugues, L]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Welin M]]
[[Category: Welin, M]]
[[Category: Fatty acid metabolism]]
[[Category: Hotdog fold]]
[[Category: Hydrolase]]
[[Category: Lipid metabolism]]
[[Category: Serine esterase]]
[[Category: Sgc]]

Latest revision as of 15:03, 30 August 2023

Human Acyl-coenzyme A thioesterase 12Human Acyl-coenzyme A thioesterase 12

Structural highlights

3b7k is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACO12_HUMAN Hydrolyzes acetyl-CoA to acetate and CoA.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Suematsu N, Isohashi F. Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase. Acta Biochim Pol. 2006;53(3):553-61. Epub 2006 Sep 2. PMID:16951743

3b7k, resolution 2.70Å

Drag the structure with the mouse to rotate

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OCA
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