1z7n: Difference between revisions

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-[[Image:1z7n.gif|left|200px]]
- {{Structure
+==ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis with bound PRPP substrate==
-|PDB= 1z7n |SIZE=350|CAPTION= <scene name='initialview01'>1z7n</scene>, resolution 3.25&Aring;
+<StructureSection load='1z7n' size='340' side='right'caption='[[1z7n]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene>
+<table><tr><td colspan='2'>[[1z7n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7N FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
-|GENE= hisZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis]), hisG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7n OCA], [https://pdbe.org/1z7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7n RCSB], [https://www.ebi.ac.uk/pdbsum/1z7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7n ProSAT]</span></td></tr>
-|RELATEDENTRY=[[1z7m|1Z7M]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7n OCA], [http://www.ebi.ac.uk/pdbsum/1z7n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z7n RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/HISZ_LACLA HISZ_LACLA] Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.[HAMAP-Rule:MF_00125]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7n_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z7n ConSurf].
+<div style="clear:both"></div>
-'''ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis with bound PRPP substrate'''
+==See Also==
+*[[ATP Phosphoribosyl Transferase|ATP Phosphoribosyl Transferase]]
+*[[ATP phosphoribosyl transferase 3D structures|ATP phosphoribosyl transferase 3D structures]]
-==About this Structure==
+__TOC__
-Z7N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7N OCA].
+</StructureSection>
-[[Category: ATP phosphoribosyltransferase]]
 [[Category: Lactococcus lactis]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Champagne, K S.]]
+[[Category: Champagne KS]]
-[[Category: Doublie, S.]]
+[[Category: Doublie S]]
-[[Category: Francklyn, C S.]]
+[[Category: Francklyn CS]]
-[[Category: Larrabee, Y.]]
+[[Category: Larrabee Y]]
-[[Category: Sissler, M.]]
+[[Category: Sissler M]]
-[[Category: allosteric]]
-[[Category: atp-prt]]
-[[Category: histidine biosynthesis]]
-[[Category: hiszg]]
-[[Category: prpp]]
-[[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:23 2008''