|
|
| (8 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| <StructureSection load='' size='450' side='right' caption='Human Rac1 (magenta) complex with YpkA (cyan), GDP and Mg+2 ion (green) (PDB code [[2h7v]])' scene='75/752232/Cv/1' pspeed='8'> | | <StructureSection load='' size='350' side='right' caption='Human Rac1 (magenta) complex with YpkA (cyan), GDP and Mg+2 ion (green) (PDB code [[2h7v]])' scene='75/752232/Cv/1' pspeed='8'> |
|
| |
|
| == Function == | | == Function == |
| The small G-protein '''Rac''' or '''Ras-related C3 botulinum toxin substrate'''. '''Ras1''' is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes<ref>PMID:23412604</ref>. '''Ras3''' binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions. | | The small G-protein '''Rac''' or '''Ras-related C3 botulinum toxin substrate'''. |
| | *'''Rac1''' is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes<ref>PMID:23412604</ref>. |
| | *'''Rac2''' is expressed in hematopoietic cells exclusively<ref>PMID:32542921</ref>. |
| | * '''Rac3''' binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions. |
|
| |
|
| == Disease == | | == Disease == |
| Line 8: |
Line 11: |
|
| |
|
| == Structural highlights == | | == Structural highlights == |
| The interactions between Rac1 and YpkA are via <scene name='75/752232/Cv/7'>switch I and switch II of Rac1 and a helical portion of the protein kinase YpkA</scene><ref>PMID:16959567</ref>. <scene name='75/752232/Cv/6'>GDP binding site on Rac1</scene>. | | The interactions between Rac1 and YpkA are via <scene name='75/752232/Cv/8'>switch I and switch II of Rac1 and a helical portion of the protein kinase YpkA</scene><ref>PMID:16959567</ref>. <scene name='75/752232/Cv/9'>GDP binding site on Rac1</scene>. |
|
| |
|
| </StructureSection>
| |
| ==3D structures of Rac== | | ==3D structures of Rac== |
| | [[Rac 3D structures]] |
|
| |
|
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| |
| | |
| *Rac1
| |
| | |
| **[[3th5]], [[1ryh]], [[1mh1]] – hRac1 + GNP – human<br />
| |
| **[[2p2l]], [[1ryf]] – hRac1 + GDP <br />
| |
| **[[4gzl]], [[3sbd]], [[3sbe]] – hRac1 (mutant) + GNP <br />
| |
| **[[4gzm]] – hRac1 (mutant) + GSP <br />
| |
| **[[5hzh]], [[2wkp]], [[2wkq]], [[2wkr]] – hRac1 LOV2 domain (mutant) + GTP + MFN <br />
| |
| **[[5vcu]] - Rac1 + GDP - ''Naegleria fowleri''<br />
| |
| | |
| *Rac1 complex with protein
| |
| | |
| **[[5fi0]] – hRac1 + PTDINS (3,4,5)-dependent Rac exchanger <br />
| |
| **[[4yon]] – hRac1 (mutant) + PTDINS (3,4,5)-dependent Rac exchanger <br />
| |
| **[[2yin]] – hRac1 + dedicator of cytokinesis protein 2 <br />
| |
| **[[3b13]] – hRac1 (mutant) + dedicator of cytokinesis protein 2 <br />
| |
| **[[3bji]], [[2vrw]] – hRac1 + proto-oncogene VAV <br />
| |
| **[[2nz8]] – hRac1 + triple functional domain protein<br />
| |
| **[[1foe]] – hRac1 + TIAM1 <br />
| |
| **[[2nz8]] - hRac1 + TRIO N-terminal<br />
| |
| | |
| *Rac1 complex with protein and nucleotide
| |
| | |
| **[[3ryt]] – hRac1 (mutant) + plexin-A1 + GNP<br />
| |
| **[[3su8]], [[3sua]] – hRac1 (mutant) + plexin-B1 + GNP<br />
| |
| **[[2rmk]] – hRac1 (mutant) + PRK1 + GCP - NMR<br />
| |
| **[[2fju]] – hRac1 + phospholipase C beta 2 + GSP <br />
| |
| **[[2h7v]] – hRac1 (mutant) + YpkA + GDP <br />
| |
| **[[1hh4]], [[1ds6]] – hRac1 + RhoGD1 + GDP <br />
| |
| **[[1i4d]], [[1i4l]] – hRac1 + arfaptin + GDP <br />
| |
| **[[1i4t]] – hRac1 + arfaptin + GNP <br />
| |
| **[[1g4u]] – hRac1 (mutant) + SPTP + GDP <br />
| |
| **[[1he1]] – hRac1 + GTPase-activating protein + GDP <br />
| |
| **[[1e96]] – hRac1 (mutant) + neutrophil cytosol factor 2 + GTP <br />
| |
| **[[5o33]] - hRac1 + kalirin + GDP<br />
| |
| | |
| *Rac2
| |
| | |
| **[[2w2t]] – hRac2 (mutant) + GDP <br />
| |
| **[[2w2v]] – hRac2 (mutant) + GDTP <br />
| |
| **[[2w2x]] – hRac2 (mutant) + PLCG2 + GSP <br />
| |
| | |
| *Rac3
| |
|
| |
|
| **[[2qme]] – hRac3 + PAK1 + GCP <br />
| |
| **[[2ov2]] – hRac3 + PAK4 + GCP <br />
| |
| **[[2ic5]] – hRac3 + GDP + GNP <br />
| |
| **[[2g0n]], [[2c2h]] – hRac3 + GDP <br />
| |
| }}
| |
| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |