Factor XIII: Difference between revisions
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[[1f13]] - hFXIII zymogen subunit A dimer<br /> | [[1f13]] - hFXIII zymogen subunit A dimer<br /> | ||
[[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | [[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | ||
[[5mhl]], [[5mhm]], [[5mhn]], [[5mho]] - hFXIII subunit A (mutant) + peptide inhibitor<br /> | |||
[[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | [[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | ||
[[1de7]] – hFXIII activation peptide + α-thrombin<br /> | [[1de7]] – hFXIII activation peptide + α-thrombin<br /> | ||
Latest revision as of 12:38, 22 May 2018
FunctionFactor XIII (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide[1]. DiseaseFXIII deficiency causes internal bleeding. |
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3D Structures of Factor XIII3D Structures of Factor XIII
Updated on 22-May-2018
1ggt – hFXIII - human
1ex0 – hFXIII zymogen (mutant)
1fie – hFXIII subunit A
1f13 - hFXIII zymogen subunit A dimer
4kty - hFXIII subunit A + peptide-like ligand
5mhl, 5mhm, 5mhn, 5mho - hFXIII subunit A (mutant) + peptide inhibitor
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion
1de7 – hFXIII activation peptide + α-thrombin
ReferencesReferences
- ↑ Laki K, Lorand L. On the Solubility of Fibrin Clots. Science. 1948 Sep 10;108(2802):280. PMID:17842715 doi:http://dx.doi.org/10.1126/science.108.2802.280