2oc3: Difference between revisions
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==Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 18== | ==Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 18== | ||
<StructureSection load='2oc3' size='340' side='right' caption='[[2oc3]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2oc3' size='340' side='right'caption='[[2oc3]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2oc3]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2oc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OC3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oc3 OCA], [https://pdbe.org/2oc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2oc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oc3 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PTN18_HUMAN PTN18_HUMAN] Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/2oc3_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/2oc3_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2oc3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2oc3" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Alfano | [[Category: Alfano I]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Barr | [[Category: Barr A]] | ||
[[Category: Bunkoczi | [[Category: Bunkoczi G]] | ||
[[Category: Debreczeni | [[Category: Debreczeni JE]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Eswaran J]] | ||
[[Category: Eswaran | [[Category: Gorrec F]] | ||
[[Category: Gorrec | [[Category: Knapp S]] | ||
[[Category: Knapp | [[Category: Papagrigoriou E]] | ||
[[Category: Papagrigoriou | [[Category: Savitsky P]] | ||
[[Category: Sobott F]] | |||
[[Category: Savitsky | [[Category: Sundstrom M]] | ||
[[Category: Sobott | [[Category: Turnbull A]] | ||
[[Category: Sundstrom | [[Category: Ugochukwu E]] | ||
[[Category: Turnbull | [[Category: Umeano C]] | ||
[[Category: Ugochukwu | [[Category: Weigelt J]] | ||
[[Category: Umeano | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||