2foi: Difference between revisions
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==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase.== | ==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase.== | ||
<StructureSection load='2foi' size='340' side='right' caption='[[2foi]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2foi' size='340' side='right'caption='[[2foi]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2foi]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2foi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FOI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JPA:4-(2,4-DICHLOROPHENOXY)-2-METHYLBIPHENYL-3-OL'>JPA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2foi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2foi OCA], [https://pdbe.org/2foi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2foi RCSB], [https://www.ebi.ac.uk/pdbsum/2foi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2foi ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/C6KSZ2_PLAF7 C6KSZ2_PLAF7] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/2foi_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/2foi_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2foi" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2foi" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Anderson | [[Category: Plasmodium falciparum 3D7]] | ||
[[Category: Fidock | [[Category: Anderson JW]] | ||
[[Category: Freundlich | [[Category: Fidock DA]] | ||
[[Category: Jacobs | [[Category: Freundlich JS]] | ||
[[Category: Jacobus | [[Category: Jacobs Jr WR]] | ||
[[Category: Karagyozov | [[Category: Jacobus DP]] | ||
[[Category: Kuo | [[Category: Karagyozov L]] | ||
[[Category: Lucumi | [[Category: Kuo M]] | ||
[[Category: Sacchettini | [[Category: Lucumi E]] | ||
[[Category: Schiehser | [[Category: Sacchettini JC]] | ||
[[Category: Shieh | [[Category: Schiehser GA]] | ||
[[Category: Tsai | [[Category: Shieh H]] | ||
[[Category: Valderramos | [[Category: Tsai H]] | ||
[[Category: Yu | [[Category: Valderramos J]] | ||
[[Category: Yu M]] | |||