Tubulin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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-<StructureSection load='1z5w' size='400' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'>
+<StructureSection load='' size='350' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'>
 == Function ==
-[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP.  See also [[Beta tubulin]].  '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes.  '''FtsZ'''  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See also [[Beta tubulin]].
+[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes.  Tubulin filaments are stabilized by taxol and zampanolide.  '''FtsZ'''  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See [[Cell division protein]] and [[Beta tubulin]].
 == Relevance ==
 The chemotherapeutic drug Taxol interacts with TUBB.  See [[Molecular Playground/Taxol]].  TUBA and TUBB expression in polyps of invasive colon cancer is different from normal<ref>PMID:16101133</ref>.
+See [[Paclitaxel]].
 == Disease ==
@@ Line 12: / Line 14: @@
 == Structural highlights ==
-*<scene name='43/430888/Cv/5'>γ-tubulin interactions with GTP and Mg+2 ion</scene> ([[1z5w]]).
+*<scene name='43/430888/Cv/6'>γ-tubulin interactions with GTP and Mg+2 ion</scene> ([[1z5w]]).
-</StructureSection>
 == 3D Structures of Tubulin ==
+[[Tubulin 3D Structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*α-tubulin
-**[[2bto]] – PdTUBA+thioredoxin 1 – ''Prosthecobacter dejongeii''<br />
-**[[2e4h]] – hTUBA C terminal + restin CAP-Gly domain 2 – human<br />
-*α-tubulin + β-tubulin
-**[[1jff]] - bTUBA+bTUBB - bovine<br />
-**[[3j6f]] - pTUBA+pTUBB – pig - Cryo EM <br />
-**[[3j6e]] - pTUBA+pTUBB +GMPCPP – Cryo EM <br />
-**[[3j7i]] - pTUBA+pTUBB +GTP – Cryo EM<br />
-**[[1tub]] - pTUBA+pTUBB – electron diffraction<br />
-**[[2btq]] – PdTUBA+PdTUBB<br />
-**[[5w3f]] - yTUBA+yTUBB + GDP + GTP - yeast<br />
-**[[5w3j]] - yTUBA+yTUBB (mutant) + GDP + GTP + taxol<br />
-**[[5ubq]], [[5ucy]] - TUBA+ TUBB  – ''Tetrahymena thermophila'' - Cryo EM <br />
-*α-tubulin + β-tubulin complexes with stathmin
-**[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]], [[4eb6]] – sTUBA+sTUBB+stathmin-4 – sheep<br />
-**[[4f61]] - sTUBA+sTUBB+stathmin-like protein R4<br />
-**[[3ut5]] - sTUBA+sTUBB+stathmin-4 + vinca peptide<br />
-**[[4eb6]] - sTUBA+sTUBB+stathmin-4<br />
-**[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]] - sTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + dolastatin + colchicine<br />
-**[[5kx5]] - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ADP + inhibitor<br />
-**[[5eyp]] - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + colchicine<br />
-**[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br />
-**[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br />
-**[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]], [[1ffx]] – bTUBA1C+bTUBB2B+stathmin-4<br />
-**[[4o2a]], [[4iij]], [[4i55]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase<br />
-**[[4wbn]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative<br />
-**[[5jh7]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + eribulin<br />
-**[[5la6]], [[5m7e]], [[5bmv]], [[5lov]], [[5lxt]], [[5lxj]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5mf4]], [[5ov7]], [[5lxs]], [[5xlt]], [[5o7a]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + inhibitor<br />
-**[[5njh]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + triazolopyrimidine<br />
-**[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + auristatin anti-mitotics<br />
-**[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + colchicine<br />
-**[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], [[4zhq]], [[4zi7]], [[4zol]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + valinamide derivative<br />
-**[[4ihj]] - bTUBA+bTUBB+stathmin-4 + tubulin Tyr-ligase + ADP<br />
-*α-tubulin + β-tubulin complex with kinesin
-**[[4lnu]] - sTUBA+sTUBB + ankyrin repeat protein + GDP + GTP + kinesin heavy chain <br />
-**[[2wbe]] – bTUBA1D+bTUBB2B+kinesin+AMPPNP <br />
-**[[3dco]] - bTUBA+bTUBB+kinesin-like NOD<br />
-**[[4ck5]], [[4ck6]], [[4ck7]] - bTUBA+bTUBB+kinesin-like KIF11 motor domain<br />
-**[[5mio]] - bTUBA+bTUBB+kinesin-like KIF2C motor domain<br />
-**[[5hnw]], [[5hnx]], [[5hny]], [[5hnz]] – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + taxol<br />
-**[[3edl]] - bTUBA1D+bTUBB2B+kinesin motor domain<br />
-**[[4hna]] - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein<br />
-**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxy]] - bTUBA+bTUBB + kinesin motor domain + GDP + GTP + taxol – Cryo EM<br />
-**[[4uxt]], [[4uy0]] - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + taxol – Cryo EM<br />
-**[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br />
-**[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br />
-**[[2hxf]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP <br />
-**[[3j6h]] - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM <br />
-**[[3j8x]] - pTUBA+pTUBB +GDP + GTP + kinesin heavy chain – Cryo EM <br />
-**[[3j8y]] - pTUBA+pTUBB +GDP + GTP + ATP + kinesin heavy chain – Cryo EM <br />
-**[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br />
-**[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br />
-**[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br />
-**[[5nd3]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP – Cryo EM<br />
-**[[5nd2]], [[5nd4]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP + ADP – Cryo EM<br />
-**[[5nd7]] - bTUBA+bTUBB+kinesin-like KIF20A + AMPPNP – Cryo EM<br />
-**[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br />
-**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br />
-**[[5o09]] - TUBA+TUBB +GDP + GTP + kinesin light chain – ''Prosthecobacter dejongeii'' - Cryo EM <br />
-*α-tubulin + β-tubulin other complexes
-**[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br />
-**[[1tvk]] - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography<br />
-**[[3iz0]] - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br />
-**[[3j1t]], [[3j1u]] - bTUBA+bTUBB+ dynein<br />
-**[[3j6p]] - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM<br />
-**[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br />
-**[[5kmg]] - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM <br />
-**[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br />
-**[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br />
-**[[5nqu]], [[5nqt]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP<br />
-**[[5nm5]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP + colchicine<br />
-**[[5m50]], [[5m54]], [[5m5c]] - bTUBA+bTUBB + calmodulin-regulated spectrin-associated protein + GDP + GTP - Cryo EM<br />
-**[[4ffb]], [[4u3j]] - yTUBA+TUBB (mutant) + protein STU2 <br />
-*γ-tubulin
-**[[3cb2]] – hTUBG1+GDP<br />
-**[[1z5v]] - hTUBG1+GTPgS<br />
-**[[1z5w]] - hTUBG1+GTP<br />
-**[[3rip]] – hTUBG4<br />
-* FtsZ
-**[[2vxy]], [[2vam]] – BsFtsZ - ''Bacillus subtilis''<br />
-**[[2ve8]] – PaFtsZ gamma domain – ''Pseudomonas aeruginosa''<br />
-**[[2r6r]]– AaFtsZ - ''Aquifex aeolicus''<br />
-**[[1w59]], [[1fsz]] – MjFtsZ - ''Methancaldococcus jannaschii''<br />
-**[[1w5e]], [[1w5f]] – MjFtsZ (mutant) <br />
-**[[3v3t]] – FtsZ (mutant) – ''Clostridium botulinum''<br />
-**[[3zid]] – FtsZ – ''Methanosaeta thermophila''<br />
-**[[3vo9]], [[3vpa]] - SaFtsZ – ''Staphylococcus aureus''<br />
-**[[3wgj]], [[3wgk]] – SaFtsZ (mutant) <br />
-*FtsZ complexes
-**[[2rhh]], [[2rhj]] – BsFtsZ+SO4 <br />
-**[[2rhl]] - BsFtsZ+GDP<br />
-**[[2rho]] - BsFtsZ+GDP+GTP-gamma-S<br />
-**[[4u39]] – BsFtsZ + cell division factor<br />
-**[[2ve9]] - PaFtsZ gamma domain+DNA<br />
-**[[2vaw]] – PaFtsZ+GDP<br />
-**[[1ofu]] - PaFtsZ+SULA<br />
-**[[2r75]] - AaFtsZ+8-morpholino-GTP <br />
-**[[2q1x]], [[1rq2]] - MtFtsZ+citrate – ''Mycobacterium tuberculosis''<br />
-**[[2q1y]], [[1rlu]] - MtFtsZ+GTP-gamma-S<br />
-**[[1rq7]], [[4kwe]], [[5v68]] - MtFtsZ+GDP<br />
-**[[2vap]] – MjFtsZ+GDP <br />
-**[[1w58]] - MjFtsZ+GMPCPP<br />
-**[[1w5a]] - MjFtsZ+MgGTP<br />
-**[[1w5b]] - MjFtsZ+GTP<br />
-**[[4b45]] – HvFtsZ + GTP-γS – ''Haloferax volcanii''<br />
-**[[3vo8]], [[3voa]], [[5h5g]] - SaFtsZ + GDP <br />
-**[[3wgl]], [[5xdw]], [[5h5h]], [[5h5i]], [[5mn4]], [[5mn6]] – SaFtsZ (mutant) + GDP<br />
-**[[3wgn]] – SaFtsZ + GTP-γS<br />
-**[[3wgm]], [[5mn5]], [[5mn7]], [[5mn8]] – SaFtsZ (mutant) + GTP<br />
-**[[3vob]], [[5xdt]], [[5xdu]] - SaFtsZ + GDP + inhibitor<br />
-**[[5xdv]] - SaFtsZ (mutant) + GDP + inhibitor<br />
-**[[4dxd]] - SaFtsZ + antibiotic <br />
-**[[4b46]] - HvFtsZ + GDP <br />
-**[[4m8i]] - SeFtsZ + GDP – ''Staphylococcus epidermitis''<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]