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==Endoplasmic reticulum protein Rp19 O95881==
==Endoplasmic reticulum protein Rp19 O95881==
<StructureSection load='1sen' size='340' side='right' caption='[[1sen]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='1sen' size='340' side='right'caption='[[1sen]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1sen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SEN FirstGlance]. <br>
<table><tr><td colspan='2'>[[1sen]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SEN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.199&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLP19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sen OCA], [http://pdbe.org/1sen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sen RCSB], [http://www.ebi.ac.uk/pdbsum/1sen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sen ProSAT], [http://www.topsan.org/Proteins/SECSG/1sen TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sen OCA], [https://pdbe.org/1sen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sen RCSB], [https://www.ebi.ac.uk/pdbsum/1sen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sen ProSAT], [https://www.topsan.org/Proteins/SECSG/1sen TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TXD12_HUMAN TXD12_HUMAN]] Possesses significant protein thiol-disulfide oxidase activity.<ref>PMID:12761212</ref>
[https://www.uniprot.org/uniprot/TXD12_HUMAN TXD12_HUMAN] Possesses significant protein thiol-disulfide oxidase activity.<ref>PMID:12761212</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/1sen_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/1sen_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Chen, L]]
[[Category: Large Structures]]
[[Category: Dailey, H A]]
[[Category: Chen L]]
[[Category: Dailey, T A]]
[[Category: Dailey HA]]
[[Category: Lee, D]]
[[Category: Dailey TA]]
[[Category: Liu, Z J]]
[[Category: Lee D]]
[[Category: Mayer, M R]]
[[Category: Liu Z-J]]
[[Category: Richardson, D C]]
[[Category: Mayer MR]]
[[Category: Richardson, J S]]
[[Category: Richardson DC]]
[[Category: Rose, J P]]
[[Category: Richardson JS]]
[[Category: Structural genomic]]
[[Category: Rose JP]]
[[Category: Shah, A]]
[[Category: Shah A]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Wang, B C]]
[[Category: Wang B-C]]
[[Category: Endoplasmic reticulum]]
[[Category: PSI, Protein structure initiative]]
[[Category: Rp19]]
[[Category: Secsg]]
[[Category: Unknown function]]

Latest revision as of 11:31, 1 May 2024

Endoplasmic reticulum protein Rp19 O95881Endoplasmic reticulum protein Rp19 O95881

Structural highlights

1sen is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.199Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

TXD12_HUMAN Possesses significant protein thiol-disulfide oxidase activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Alanen HI, Williamson RA, Howard MJ, Lappi AK, Jantti HP, Rautio SM, Kellokumpu S, Ruddock LW. Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member. J Biol Chem. 2003 Aug 1;278(31):28912-20. Epub 2003 May 21. PMID:12761212 doi:10.1074/jbc.M304598200

1sen, resolution 1.20Å

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