2b2x: Difference between revisions
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==VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab== | ==VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab== | ||
<StructureSection load='2b2x' size='340' side='right' caption='[[2b2x]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2b2x' size='340' side='right'caption='[[2b2x]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2b2x]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2b2x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2X FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2x OCA], [https://pdbe.org/2b2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2x RCSB], [https://www.ebi.ac.uk/pdbsum/2b2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2x ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ITA1_RAT ITA1_RAT] Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2x_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2x_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
*[[3D structures of antibody|3D structures of antibody]] | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[Integrin 3D structures|Integrin 3D structures]] | |||
*[[3D structures of non-human antibody|3D structures of non-human antibody]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Boriack-Sjodin | [[Category: Rattus norvegicus]] | ||
[[Category: Clark | [[Category: Boriack-Sjodin PA]] | ||
[[Category: Eldredge | [[Category: Clark LA]] | ||
[[Category: Fitch | [[Category: Eldredge J]] | ||
[[Category: Friedman | [[Category: Fitch C]] | ||
[[Category: Hanf | [[Category: Friedman B]] | ||
[[Category: Jarpe | [[Category: Hanf KJ]] | ||
[[Category: Li | [[Category: Jarpe M]] | ||
[[Category: Liparoto | [[Category: Li Y]] | ||
[[Category: Lugovskoy | [[Category: Liparoto SF]] | ||
[[Category: Lugovskoy A]] | |||