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==VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab==
==VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab==
<StructureSection load='2b2x' size='340' side='right' caption='[[2b2x]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2b2x' size='340' side='right'caption='[[2b2x]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2b2x]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B2X FirstGlance]. <br>
<table><tr><td colspan='2'>[[2b2x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mhp|1mhp]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Itga1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2x OCA], [https://pdbe.org/2b2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2x RCSB], [https://www.ebi.ac.uk/pdbsum/2b2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2x OCA], [http://pdbe.org/2b2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b2x RCSB], [http://www.ebi.ac.uk/pdbsum/2b2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ITA1_RAT ITA1_RAT]] Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.  
[https://www.uniprot.org/uniprot/ITA1_RAT ITA1_RAT] Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2x_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2x_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[3D structures of antibody|3D structures of antibody]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Integrin 3D structures|Integrin 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Boriack-Sjodin, P A]]
[[Category: Rattus norvegicus]]
[[Category: Clark, L A]]
[[Category: Boriack-Sjodin PA]]
[[Category: Eldredge, J]]
[[Category: Clark LA]]
[[Category: Fitch, C]]
[[Category: Eldredge J]]
[[Category: Friedman, B]]
[[Category: Fitch C]]
[[Category: Hanf, K J]]
[[Category: Friedman B]]
[[Category: Jarpe, M]]
[[Category: Hanf KJ]]
[[Category: Li, Y]]
[[Category: Jarpe M]]
[[Category: Liparoto, S F]]
[[Category: Li Y]]
[[Category: Lugovskoy, A]]
[[Category: Liparoto SF]]
[[Category: Antibody-antigen complex]]
[[Category: Lugovskoy A]]
[[Category: Computational design]]
[[Category: Immune system]]

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