Succinate-semialdehyde dehydrogenase: Difference between revisions
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (6 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code [[3vz3]]).' scene='59/590825/Cv/2'> | ||
== Function == | == Function == | ||
'''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. | '''Succinate-semialdehyde dehydrogenase''' or '''α-ketoglutaric semialdehyde dehydrogenase''' or '''succinyl-CoA reductase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. See also [[Aldehyde dehydrogenase]]. | ||
== Disease == | == Disease == | ||
| Line 10: | Line 11: | ||
== Structural highlights == | == Structural highlights == | ||
The active site of SSD contains the <scene name='59/590825/Cv/4'>substrate succinate semialdehyde</scene> and the <scene name='59/590825/Cv/ | The active site of SSD contains the <scene name='59/590825/Cv/4'>substrate succinate semialdehyde</scene> and the <scene name='59/590825/Cv/11'>cofactor NADP</scene><ref>PMID:23500184</ref>. Water molecules are shown as red spheres. <scene name='59/590825/Cv/12'>Whole binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
| Line 20: | Line 22: | ||
*Succinate-semialdehyde dehydrogenase | *Succinate-semialdehyde dehydrogenase | ||
**[[2w8n]], [[2w8o]] – hSSD - human <br /> | |||
**[[2w8p]] – hSSD (mutant) <br /> | |||
**[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br /> | **[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br /> | ||
**[[3vz2]] – SySSD (mutant) <br /> | **[[3vz2]] – SySSD (mutant) <br /> | ||
| Line 25: | Line 29: | ||
**[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br /> | **[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br /> | ||
**[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br /> | **[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br /> | ||
**[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br /> | **[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br /> | ||
**[[5x5t]] – AbSSD – ''Azuspirillum brasilense'' <br /> | |||
*Succinate-semialdehyde dehydrogenase complexes | *Succinate-semialdehyde dehydrogenase complexes | ||
| Line 39: | Line 42: | ||
**[[4oht]] – SpSSD + NADPH<br /> | **[[4oht]] – SpSSD + NADPH<br /> | ||
**[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br /> | **[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br /> | ||
**[[5x5u]] – AbSSD + NAD<br /> | |||
**[[8c54]] – SSD + NADH – ''Rhizobium leguminosarum'' – Cryo EM<br /> | |||
**[[8cej]] – CkSSD + mesaconyl-c1-CoA – ''Clostridium kluyveri''<br /> | |||
**[[8cek]] – CkSSD + NADPH<br /> | |||
}} | }} | ||